The Microbiome of Prostate Fluid Is Associated With Prostate Cancer

Frontiers in Microbiology
Xiaowei MaWei Xue

Abstract

To explore the microbiome of the prostatic fluid in high prostate-specific antigen (PSA) patients. The microbiome profiles of prostatic fluid samples from 32 prostate cancer (PCa) patients and 27 non-PCa people were assessed. Microbiome analysis was assessed by massive 16S ribosomal RNA gene sequencing. Compared with the NCA group, the microbial diversity was lower in the CA group. There were no specific microbial species in the CA group or NCA group. However, many species, such as those in the genera Alkaliphilus, Enterobacter, Lactococcus, Cronobacter, Carnobacterium, and Streptococcus, showed a significant difference between the CA group and NCA group. The prostate contains reduced bacteria, suggesting a possible pathophysiological correlation between the composition of the microbiome and PCa. Meanwhile, this study uncovered that the microbiome may be beneficial in maintaining the stability of the microenvironment of the prostate and provides interesting perspectives for the identification of novel biomarkers in high-PSA patients.

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Citations

Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Holger Brüggemann, Munir A Al-Zeer
Jul 2, 2020·Frontiers of Medicine·Solmaz Ohadian Moghadam, Seyed Ali Momeni
Dec 31, 2020·Medicinal Research Reviews·Cheng FangXian-Tao Zeng
Nov 6, 2020·Cancer Research·Sheetal Parida, Dipali Sharma

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Methods Mentioned

BETA
biopsy
PCR
PCA

Software Mentioned

FLASH
RDP Classifier
randomForest
MegaBLAST
UCHIME
SPSS
R
UPARSE
Trimmomatic

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