The microbiome of the gut in critically ill patients

Medizinische Klinik, Intensivmedizin und Notfallmedizin
B Salzberger, C Rauscher

Abstract

The complexity and diversity of the human intestinal microbiome has only recently been characterized. The multiple metabolic and immunologic effects of the bacterial flora have demonstrated the symbiosis between the microbiome and its host. This symbiosis is disturbed in a multitude of diseases, especially in critically ill patients. A review of the changes in the intestinal microbiome of critically ill patients and the use of probiotics. Nonsystematic literature search in PubMed on the topics: (1) changes in the intestinal microbiome in critically ill patients, (2) interventions using probiotics in critically ill patients, and (3) use of fecal transplantation in Clostridium difficile colitis. Trauma, sepsis, systemic inflammatory response syndrome, and other conditions lead to shifts in the composition of the intestinal microbiome, which are correlated with clinical outcome. The most obvious change is a profound loss of obligate anaerobe bacteria, leading also to metabolic changes. Probiotics have been used in several studies and show efficacy in the reduction of infectious complication but not in overall mortality. C. difficile colitis as the model disease for a disturbed microbiome can be treated effectively by transfer of d...Continue Reading

References

Oct 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J G Bartlett
Feb 17, 2006·Nature Immunology·Jason M BrenchleyDaniel C Douek
Jul 19, 2007·Nature Reviews. Microbiology·Alan Walker
Sep 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Les Dethlefsen, David A Relman
Nov 26, 2010·Digestive Diseases and Sciences·Kentaro ShimizuHisashi Sugimoto
Mar 9, 2011·Digestive Diseases and Sciences·Mineji HayakawaSatoshi Gando
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Jul 11, 2012·Critical Care : the Official Journal of the Critical Care Forum·Akinori OsukaTakeshi Shimazu
Sep 15, 2012·Critical Care Medicine·Elaine O PetrofDaren K Heyland
Jan 18, 2013·The New England Journal of Medicine·Els van NoodJosbert J Keller
Mar 5, 2013·Trends in Microbiology·Tim J SchuijtW Joost Wiersinga
Sep 24, 2013·Trends in Molecular Medicine·Rohit Mittal, Craig M Coopersmith
Apr 26, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ilan YoungsterElizabeth L Hohmann
May 9, 2015·World Journal of Gastroenterology : WJG·Noortje G RossenCyriel Y Ponsioen

❮ Previous
Next ❯

Citations

Feb 22, 2017·Microbial Pathogenesis·Jing-Zhang WangZhi-Jun Liu
Jul 12, 2018·Medizinische Klinik, Intensivmedizin und Notfallmedizin·F Prechter, A Stallmach

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Cellular Immunometabolism

Immunometabolism involves not only the way metabolites are digested by the immune system, but the way in which they can alter the pathway of the immune system. These responses occur in day-to-day healthy cell functioning, but can result in diseases, such as autoimmune disorders. Discover the latest research on cellular immunometabolism here.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Takeshi KamiyaTakashi Joh
Annali Dell'Istituto Superiore Di Sanità
G GentileG Panichi
© 2021 Meta ULC. All rights reserved