The Microbiota-Inflammasome Hypothesis of Major Depression

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Antonio InserraMa-Li Wong

Abstract

We propose the "microbiota-inflammasome" hypothesis of major depressive disorder (MDD, a mental illness affecting the way a person feels and thinks, characterized by long-lasting feelings of sadness). We hypothesize that pathological shifts in gut microbiota composition (dysbiosis) caused by stress and gut conditions result in the upregulation of pro-inflammatory pathways mediated by the Nod-like receptors family pyrin domain containing 3 (NLRP3) inflammasome (an intracellular platform involved in the activation of inflammatory processes). This upregulation exacerbates depressive symptomatology and further compounds gut dysbiosis. In this review we describe MDD/chronic stress-induced changes in: 1) NLRP3 inflammasome; 2) gut microbiota; and 3) metabolic pathways; and how inflammasome signaling may affect depressive-like behavior and gut microbiota composition. The implication is that novel therapeutic strategies could emerge for MDD and co-morbid conditions. A number of testable predictions surface from this microbiota-gut-inflammasome-brain hypothesis of MDD, using approaches that modulate gut microbiota composition via inflammasome modulation, fecal microbiota transplantation, psychobiotics supplementation, or dietary change.

References

Jul 1, 1991·Endocrinology·J LicinioP W Gold
Mar 1, 1994·Neuroimmunomodulation·M L Wong, J Licinio
Oct 24, 2002·The Journal of Biological Chemistry·Fang Yan, D Brent Polk
Aug 28, 2003·Scandinavian Journal of Gastroenterology·H TakagiT Hibi
Sep 18, 2003·FEMS Immunology and Medical Microbiology·Karen Manon LammersMassimo Campieri
Mar 26, 2005·Science·Fredrik BäckhedJeffrey I Gordon
Aug 30, 2005·Journal of Affective Disorders·Aye-Mu MyintYong-Ku Kim
Oct 21, 2005·The New England Journal of Medicine·Turk Rhen, John A Cidlowski
May 12, 2006·International Clinical Psychopharmacology·Julien MendlewiczNicoletta Brunello
Jun 15, 2006·World Journal of Gastroenterology : WJG·Christian-U RiedelStephanie Blum
Dec 8, 2006·European Journal of Clinical Nutrition·D BentonA Brown
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Dec 23, 2008·Nature Genetics·Alexandra-Chloé VillaniDenis Franchimont
Apr 20, 2010·Psychoneuroendocrinology·Christoph AnackerCarmine M Pariante
Sep 28, 2010·Inflammatory Bowel Diseases·Simon A HirotaPaul L Beck
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
Mar 11, 2011·Trends in Immunology·Md Hasan ZakiThirumala-Devi Kanneganti
Apr 22, 2011·Nature·Manimozhiyan ArumugamPeer Bork
May 21, 2011·Immunity·Markus B GeukingAndrew J Macpherson
Jul 7, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mark Lyte
Jul 12, 2011·Gastroenterology·Delphine M SaulnierJames Versalovic
Aug 2, 2011·TheScientificWorldJournal·Donata Lissner, Britta Siegmund
Aug 23, 2011·Current Opinion in Immunology·Janet ChowSarkis K Mazmanian
Oct 21, 2011·Cell Death & Disease·B M BrinkmanP Vandenabeele
Dec 14, 2011·Frontiers in Physiology·Sue GrenhamTimothy G Dinan
Jan 14, 2012·Journal of Proteome Research·Peng ZhengPeng Xie
Jan 20, 2012·Nature·Till StrowigRichard Flavell
Feb 3, 2012·Nature·Jorge Henao-MejiaRichard A Flavell
Jun 8, 2012·Science·Jeremy K NicholsonSven Pettersson
Oct 9, 2012·Current Opinion in Pharmacology·Javier A BravoJohn F Cryan
Dec 25, 2012·Brain, Behavior, and Immunity·Masaaki IwataRonald S Duman
Feb 15, 2013·Standards in Genomic Sciences·Yoko KatanoNobuyuki Fujita
Mar 12, 2013·Gastroenterology·Kirsten TillischEmeran A Mayer

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Citations

Aug 7, 2019·Journal of Cellular Biochemistry·Jiezhong Chen, Luis Vitetta
Jun 14, 2019·Current Opinion in Psychiatry·Angelos Halaris
Sep 7, 2019·The European Journal of Neuroscience·Yu-Hao XuYue-Feng Li
Nov 14, 2019·Nutrients·María Marhuenda-MuñozAnna Vallverdú-Queralt
Sep 25, 2019·Cells·Gianfranco NataleFrancesco Fornai
Jun 17, 2020·BMC Psychiatry·Arthi Chinna MeyyappanRoumen Milev
Nov 22, 2019·Frontiers in Neuroscience·Susan Westfall, Giulio Maria Pasinetti
Jan 7, 2021·Journal of Leukocyte Biology·Chantal DonovanPhilip M Hansbro
Jan 7, 2021·The Journal of Physiology·Ciara E KeoghMélanie G Gareau
Dec 29, 2020·Frontiers in Immunology·Andrina RutschFrancesca Ronchi
Jul 21, 2020·Journal of Pharmaceutical and Biomedical Analysis·Thomas Gurry, Leonardo Scapozza
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Yue WangAilin Luo
May 4, 2021·International Journal of Colorectal Disease·Sven H LoosenChristoph Roderburg
May 1, 2021·Acta Neuropsychiatrica·Siu Wa TangBrian Leonard
Jul 13, 2021·Frontiers in Cellular and Infection Microbiology·Jing WangJun Gao
Jul 23, 2021·Scientific Reports·Yang ShenYing Liang
May 13, 2020·Journal of Agricultural and Food Chemistry·NIan ZhouMingmei Zhou

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