The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds

Neurology
S M GregoireD J Werring

Abstract

Brain microbleeds on gradient-recalled echo (GRE) T2*-weighted MRI may be a useful biomarker for bleeding-prone small vessel diseases, with potential relevance for diagnosis, prognosis (especially for antithrombotic-related bleeding risk), and understanding mechanisms of symptoms, including cognitive impairment. To address these questions, it is necessary to reliably measure their presence and distribution in the brain. We designed and systematically validated the Microbleed Anatomical Rating Scale (MARS). We measured intrarater and interrater agreement for presence, number, and anatomical distribution of microbleeds using MARS across different MRI sequences and levels of observer experience. We studied a population of 301 unselected consecutive patients admitted to our stroke unit using 2 GRE T2*-weighted MRI sequences (echo time [TE] 40 and 26 ms). Two independent raters with different MRI rating expertise identified, counted, and anatomically categorized microbleeds. At TE = 40 ms, agreement for microbleed presence in any brain location was good to very good (intrarater kappa = 0.85 [95% confidence interval (CI) 0.77-0.93]; interrater kappa = 0.68 [95% CI 0.58-0.78]). Good to very good agreement was reached for the presence ...Continue Reading

Citations

Jan 31, 2013·Seminars in Neurology·Brian L Edlow, Ona Wu
Jun 21, 2011·Brain : a Journal of Neurology·Natalie S RyanJonathan M Schott
Aug 16, 2011·Brain : a Journal of Neurology·David J SharpRobert Leech
Jun 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S-H KohS H Kim
Sep 29, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F FluriS T Engelter
Feb 16, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Andreas CharidimouDavid J Werring
Jun 28, 2013·PloS One·Hugo J KuijfKoen L Vincken
Oct 22, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jin-Biao ZhangFang Li
Nov 2, 2013·Neurosurgery·Sang-Beom JeonJan Claassen
Nov 20, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Robert HurfordDavid J Werring
Sep 4, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shinichiro MaeshimaNorio Tanahashi
May 7, 2011·AJNR. American Journal of Neuroradiology·M M A ConijnJ Hendrikse
May 26, 2012·AJNR. American Journal of Neuroradiology·L SabaM Piga
Jan 5, 2011·Brain : a Journal of Neurology·Kirsi Maria KinnunenDavid James Sharp
Dec 3, 2010·Current Opinion in Neurology·Charlotte Cordonnier
Feb 11, 2016·Fluids and Barriers of the CNS·Elias JohanssonJan Malm
Jan 13, 2016·Journal of Alzheimer's Disease : JAD·Nan WangJoe Verghese
Jun 27, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Toshio ImaizumiKatsuya Komatsu
Jun 27, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Toshio ImaizumiKatsuya Komatsu
May 28, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Timothy J Kleinig
Dec 26, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Nagaendran KandiahAmanda Ng
Sep 11, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Toshio ImaizumiKatsuya Komatsu
Jan 23, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Andreas Charidimou
Feb 5, 2016·Neurology·Susanne J van VeluwAnnemieke J M Rozemuller
Sep 21, 2010·Journal of the Neurological Sciences·David J WerringLisa Cipolotti
Nov 26, 2015·Journal of Alzheimer's Disease : JAD·Nagaendran KandiahPryseley Nkouibert Assam
Mar 13, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jean-Claude BaronYoung T Hong
Nov 13, 2015·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Amir FazlollahiUNKNOWN AIBL Research Group
Dec 22, 2015·Neurobiology of Aging·Mafalda CacciottoloCaleb E Finch
Jun 6, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Valeria KebetsDavid J Werring
Jan 13, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Oscar H Del BruttoDavid L Brown
Aug 4, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Andreas CharidimouDavid J Werring
Mar 19, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yu KonoYasuyuki Iguchi
May 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Grant McAuleyWolff Kirsch
Feb 13, 2013·Epilepsia·Sang-Beom JeonJan Claassen
Sep 15, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Ashkan ShoamaneshOscar R Benavente
Nov 5, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-H KimY J Kim
Dec 3, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Oscar H Del BruttoJulio Lama
Apr 15, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Manon BrundelGeert Jan Biessels
Feb 18, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ken KazumataKiyohiro Houkin
Dec 18, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yusuke YakushijiHideo Hara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.