PMID: 6978320Mar 1, 1982Paper

The microdosimetry of lymphocytes irradiated by alpha-particles

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
D R Fisher, R Harty

Abstract

Although the concept of absorbed dose is commonly used in radiation biology as a parameter for comparing the toxic effect of different levels of radiation on a system, there are situations where the absorbed dose by itself is inadequate, and additional dose distribution information is required to explain the observed biological effects. A good example is the irradiation of cells by alpha-particles. This paper reports the use of internal microdosimetry techniques to reinvestigate the dosimetry to two very similar experiments with apparently contradictory dose-response results. Yields of dicentric chromosome aberrations induced in human blood lymphocytes following in vitro exposure to dissolved americium or plutonium at two separate laboratories produced linear dose-response functions, but the slopes of the best-fit straight lines differed by a factor of 12. Our microdosimetric analysis showed the results of one experiment to be inconsistent with a uniform distribution of activity. It also showed that the difference in slope could be attributed to differences in particulate size and spatial distribution as a result of dissimilarities in procedures used for preparing the actinide solutions.

References

Apr 30, 1979·Radiation and Environmental Biophysics·A A EdwardsR J Purrott
Jun 13, 1975·Radiation and Environmental Biophysics·A M Kellerer, D Chmelevsky
Jan 1, 1970·Physics in Medicine and Biology·A C James, N F Kember

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Citations

Sep 5, 2003·Cancer Biotherapy & Radiopharmaceuticals·Thomas G StinchcombJohn C Roeske
Mar 22, 2005·Cancer Biotherapy & Radiopharmaceuticals·Tapan NayakRobert Atcher
Feb 9, 2007·Radiation Protection Dosimetry·R W HowellE I Azzam
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R M MacklisC N Coleman
Jan 16, 2007·Radiation Protection Dosimetry·W HofmannG Monchaux
Jul 12, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Behrooz VaziriUNKNOWN SNMMI MIRD Committee

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