PMID: 14609138Nov 12, 2003Paper

The microencapsulated ascorbic acid release in vitro and its effect on iron bioavailability

Archives of Pharmacal Research
Jun-Beum LeeHae-Soo Kwak


The present study was carried out to examine the stability of microencapsulated ascorbic acid in simulated-gastric and intestinal situation in vitro and the effect of microencapsulated ascorbic acid on iron bioavailability. Coating materials used were polyglycerol monostearate (PGMS) and medium-chain triacylglycerol (MCT), and core materials were L-ascorbic acid and ferric ammonium sulfate. When ascorbic acid was microencapsulated by MCT, the release of ascorbic acid was 6.3% at pH 5 and 1.32% at pH 2 in simulated-gastric fluids during 60 min. When ascorbic acid was microencapsulated by PGMS, the more ascorbic acid was released in the range of 9.5 to 16.0%. Comparatively, ascorbic acid release increased significantly as 94.7% and 83.8% coated by MCT and PGMS, respectively, for 60 min incubation in simulated-intestinal fluid. In the subsequent study, we tested whether ascorbic acid enhanced the iron bioavailability or not. In results, serum iron content and transferring saturation increased dramatically when subjects consumed milks containing both encapsulated iron and encapsulated ascorbic acid, compared with those when consumed uncapsulated iron or encapsulated iron without ascorbic acid. Therefore, the present data indicated ...Continue Reading


Jan 1, 1990·The American Journal of Clinical Nutrition·M S DeehrB Dawson-Hughes
Jan 1, 1982·Folia Microbiologica·R Chapman, A C Dean
Mar 20, 2001·Journal of Microencapsulation·M S UddinH J Zhu
Jul 27, 2001·Journal of Dairy Science·H S KwakJ Ahn
Dec 11, 2003·Journal of Agricultural and Food Chemistry·H S KwakJ Ahn

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May 4, 2016·Phytotherapy Research : PTR·Daniel Martín-VertedorJonathan Delgado-Adámez

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