PMID: 18409368Apr 16, 2008Paper

The microtubule system in endothelial barrier dysfunction: disassembly of peripheral microtubules and microtubules reorganization in internal cytoplasm

Tsitologiia
K M SmurovaI B Alieva

Abstract

Endothelial cell barrier dysfunction is often associated with dramatic cytoskeletal reorganization, activation of actomyosin contraction and finally gap formation. At present time the role of microtubules in endothelial cell barrier regulation is not fully understood, however a number of observations allow to assume that microtubules reaction is the extremely important part in development of endothelial dysfunction. These observations have been forced us to examine the role of microtubule system reorganization in endothelial cell barrier regulation. In quiescent endothelial cells microtubule density is the highest in the centrosome region and insignificant near the cell margin. The analysis of microtubules distribution after specific antibodies staining using the method of measurement of their fluorescence intensity has shown that in control endothelial cells the reduction of fluorescence intensity from the cell center to its periphery is described by the equation of an exponential regression. The hormone agent, thrombin (25 nM), causes rapid increase of endothelial cell barrier permeability accompanied by fast decrease in quantity of peripheral microtubules and reorganization of microtubule system in internal cytoplasm of endo...Continue Reading

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Citations

May 7, 2010·Journal of Biomedicine & Biotechnology·Irina B AlievaAlexander D Verin
Nov 12, 2014·Biochemistry. Biokhimii︠a︡·I B Alieva
Apr 17, 2012·Journal of Drug Delivery·Koji HanaiNorimasa Sawada
Sep 4, 2013·The British Journal of Sociology·Candace KruttschnittLiam Kennedy

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