The microvascular cell and ischemia-reperfusion injury

Journal of Cardiovascular Pharmacology
E D Verrier

Abstract

The vascular endothelium has a number of functions that may mediate many of the ischemia-reperfusion (IR) phenomena. The gatekeeper function is disturbed and increased capillary permeability results in edema and organ dysfunction. Vasomotor function is altered, with impairment of relaxation and augmentation of constrictor responses. Coagulation becomes imbalanced, favoring the procoagulant pathways that lead to thrombosis. Vascular adhesion molecules (integrins, selectins) are upregulated or expressed to mediate the adherence and subsequent destructive effects of neutrophils as they interact with the endothelium and the underlying organs. Finally, the more chronic vascular endothelial response may be proliferation of all cellular components of the vessel wall, leading, e.g., to intimal hyperplasia or restenosis. Ultimately, the endothelium plays a significant role either in the reparative processes that lead to recovery of the organ (myocardial stunning) or in the destructive processes that lead to cell or organ death (myocardial infarction). Our research group has been interested in the selectins, particularly E-selectin (endothelial) and P-selectin (platelet). E-selectin is not constitutively present on endothelial cells but ...Continue Reading

References

Aug 2, 1990·Nature·T A Springer
Apr 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M LeferX L Ma
Jun 1, 1990·Journal of the American College of Cardiology·J H IpJ H Chesebro
Aug 1, 1989·The Journal of Investigative Dermatology·M G Tonnesen
Aug 25, 1988·The New England Journal of Medicine·P M Vanhoutte
Feb 20, 1986·The New England Journal of Medicine·R Ross
May 1, 1994·Journal of Cardiac Surgery·I Shen, E D Verrier
Nov 1, 1993·Annals of Surgery·M G Davies, P O Hagen
Feb 1, 1993·The Annals of Thoracic Surgery·J ButlerS Westaby

❮ Previous
Next ❯

Citations

May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Serban C StoicaStephen R Large
Sep 1, 1996·The Annals of Thoracic Surgery·E D Verrier, E M Boyle
Mar 25, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·R PudilM Drahosová
Jan 1, 1998·Trends in Cardiovascular Medicine·J F Schmedtje, Y S Ji
Jun 26, 2007·Acta Pharmacologica Sinica·Chang-seng Liang
May 13, 2003·Microsurgery·Björn D KrapohlPeter Mailänder
Mar 10, 2001·The Journal of Thoracic and Cardiovascular Surgery·S MurakiJ Vinten-Johansen
Jul 17, 1998·Anesthesiology·M N Gomez
Nov 30, 1999·Anesthesia and Analgesia·R J McCarthyA D Ivankovich
Mar 29, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J GrünenfelderM Turina
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·X BaoJ A Frangos
May 19, 2004·Equine Veterinary Journal·S R Bailey
May 25, 2004·Journal of Cellular Biochemistry·Michael T WatkinsGeorge M Patton
Mar 11, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M CutaiaS Rounds
Oct 8, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaohui LiuLi Zhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.