The microvascular impact of focal nerve trunk injury

Journal of Neurotrauma
Qing-Gui XuD W Zochodne

Abstract

The microvascular supply of the peripheral nerve trunk may be rendered vulnerable by acute focal injuries, particularly if they are associated with direct injury to the epineurial blood supply. In this work we tracked the impact of three clinically relevant forms of focal nerve trunk injury on serial measures of epineurial weighted erythrocyte flux and endoneurial blood flow: short-length crush injuries, long-segmental crush injuries, and crush injuries with superimposed vascular stripping to model added direct epineurial damage. Red blood cell (RBC) flux was measured using quantitative multiple sampling laser doppler flowmetry, and endoneurial blood flow by microelectrode hydrogen clearance polarography. Both short and long crush injuries transiently reduced epineurial RBC flux, most prominently in long injuries, to 34% by 1 h after injury. The changes were less prominent when deeper flux was examined, whereas endoneurial blood flow was not altered by either injury. Long crush injury with added stripping of the epineurial blood supply was associated with more profound declines in epineurial RBC flux, to 16% by 3 h, with recovery at 14 days to 70% of that of the contralateral intact nerve trunk. There was, however, only a minim...Continue Reading

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Citations

Feb 6, 2013·The Australasian Medical Journal·Minnie Au, Stephen Rattigan
Sep 26, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hanan M El-GowelliHisham El-Saghir
Feb 24, 2012·Anesthesiology·Katherine KinghornSylvia Y Dolinski

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