The microvessel density of the hypospadiac prepuce in children

Journal of Pediatric Urology
Mustafa Cağrı SavaşSirin Başpınar

Abstract

The blood supply of the hypospadiac prepuce is crucial for success in surgery. Although the vascular anatomy of the hypospadiac prepuce has been previously documented, data on microvessel density are missing. It was aimed to document the microvessel density of the normal and hypospadiac prepuce. After ethical approval of the study, prepuces from 24 children with hypospadias undergoing surgical repair and from 9 healthy age-matched controls were stained by immunohistochemical methods using panendothelial cell antigen CD31 in order to assay their microvessel density. The microvessel density was significantly decreased in hypospadiac children when compared to controls (P<0.05). A gradual decrease in microvessel density was observed as the severity of the condition increased, indicating a significant negative correlation (r=-0.585; P<0.05). Our findings should be taken into account when considering preoperative treatments such as topical testosterone application or operative strategies for hypospadias using prepucial flaps, and also during the postoperative course, especially when it is complicated. Further studies are needed to clarify the role of vascularity in the pathogenesis of hypospadias and its consequences for surgical rep...Continue Reading

References

Jan 1, 1997·British Journal of Urology·R E el-GalleyN T Galloway
Feb 11, 2003·The Journal of Urology·Sava V Perovic, Zoran I Radojicic
Sep 28, 2004·Pediatric Surgery International·Zafar NazirResham Rehman
Nov 16, 2004·The Journal of Urology·Selcuk YucelMehmet Baykara
Mar 7, 2006·Journal of Pediatric Surgery·Laurence S Baskin, Michele B Ebbers
Dec 26, 2006·Asian Journal of Andrology·Alexander K C Leung, William L M Robson

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Citations

Jan 1, 2014·Pediatric Surgery International·Eloísio Alexsandro da SilvaRonaldo Damião
Aug 3, 2013·Journal of Pediatric Urology·Levent CeyhanBehcet Ilker Büyükyavuz
Feb 21, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Marcello CimadorEnrico de Grazia
Sep 14, 2018·Experimental and Therapeutic Medicine·Zhang ZhaoXiangming Mao

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