The midcycle gonadotropin surge in normal women occurs in the face of an unchanging gonadotropin-releasing hormone pulse frequency

The Journal of Clinical Endocrinology and Metabolism
J M AdamsJ E Hall

Abstract

The midcycle gonadotropin surge is a critical event in normal reproductive cycles and requires functional integration of the hypothalamus, pituitary, and ovary. To determine whether a change in GnRH frequency occurs coincident with the onset or termination of the surge in normal women, 20 studies were performed at a sampling interval of every 5 min for up to 36 h. The frequency of pulsatile GnRH secretion was assessed by the use of two surrogate markers of its secretion, LH and free alpha-subunit (FAS). The timing of the studies was prospectively determined by serial ultrasound and previous cycle history, whereas measurements of LH, FSH, estradiol, and progesterone in daily blood samples were used retrospectively to locate the frequent sampling study in relation to the day of ovulation in each individual. The frequent sampling studies were divided into late follicular phase (LFP; days -4 to -2) and early, mid-, and late portions of the midcycle surge (days -1 to 1) in relation to the 95% confidence limits of the LH peak derived from daily samples in 69 normal ovulatory women. The patterns of LH and FAS secretion were pulsatile at all times during the midcycle surge. The amplitude of LH pulsations increased from the LFP and earl...Continue Reading

Associated Clinical Trials

Apr 4, 2007·Janet E. Hall, MD
Feb 27, 2018·Adesola Ojo Ojoawo

Citations

Jul 20, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·James W SimpkinsCharles B Breckenridge
May 12, 2011·American Journal of Physiology. Endocrinology and Metabolism·N D ShawJ E Hall
Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Kara M KlingmanJanet E Hall
Jun 3, 2011·The Journal of Clinical Endocrinology and Metabolism·J T GeorgeR A Anderson
Sep 6, 2012·The Journal of Clinical Endocrinology and Metabolism·N D ShawJ E Hall
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Natalie D ShawJanet E Hall
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·J E Hall, S Gill
Oct 27, 2004·Endocrinology and Metabolism Clinics of North America·Janet E Hall
Jul 17, 1998·Frontiers in Neuroendocrinology·N Chabbert BuffetP Bouchard
Aug 21, 2018·The Journal of Clinical Endocrinology and Metabolism·Justine Hugon-RodinNicolas de Roux
Dec 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Yardena Tenenbaum-RakoverNicolas de Roux
Dec 15, 2015·The Journal of Clinical Endocrinology and Metabolism·G L FraserJean Combalbert
Sep 14, 2013·The Journal of Clinical Endocrinology and Metabolism·C N JayasenaW S Dhillo
Dec 10, 2014·The Journal of Clinical Endocrinology and Metabolism·N D ShawJ E Hall
Oct 27, 2015·Metallomics : Integrated Biometal Science·Li MaAnthony W Maresso

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