The mighty arginine, the stable quaternary amines, the powerful aromatics, and the aggressive phosphate: their role in the noncovalent minuet

Journal of Proteome Research
Amina S Woods

Abstract

In the age of proteomics, the role of certain amino acid residues and some post-translational modifications in noncovalent complex formation are gaining in importance, as the understanding of interactions between biological molecules, is at the heart of the structure function relationship puzzle. In this work, mass spectrometry is used to highlight ammonium- or guanidinium-aromatic interactions through Cation-pi bonds and ammonium- or guanidinium-phosphate interactions through salt bridge formation. Such interactions are crucial factors in certain ligand-receptor interactions and receptor-receptor interactions. In addition, the ability of phosphorylated residues and phosphorylated lipids to form noncovalent complexes with guanidinium and quaternary ammonium (mostly through Coulombic interactions) is demonstrated, and could explain the stability of certain membrane embedded protein, or a possible role for phosphorylation in protein-protein interactions. Dougherty's work demonstrates cation-pi interactions in intra-protein interactions and folding, the present work explores inter-peptide interactions, i.e., the formation of noncovalent complexes between peptides' epitopes containing adjacent aromatic residues and ones containing ...Continue Reading

References

May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·P Juhasz, K Biemann
Apr 26, 1996·The Journal of Biological Chemistry·K BefortB L Kieffer
Dec 24, 1997·Brain Research. Brain Research Reviews·H R Arias
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·W ZhongD A Dougherty
Oct 24, 1998·Journal of Mass Spectrometry : JMS·T B Farmer, R M Caprioli
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·J P Gallivan, D A Dougherty
Jan 6, 2001·Journal of the American Society for Mass Spectrometry·A S Woods, M A Huestis
May 18, 2001·Nature·D A Dougherty, H A Lester
Aug 10, 2001·Neurochemical Research·A Woods, A Zangen
Aug 21, 2001·The Journal of Organic Chemistry·S RensingT Schrader
Aug 23, 2001·Journal of the American Chemical Society·A Gapeev, R C Dunbar
Feb 12, 2002·Journal of the American Society for Mass Spectrometry·Amina S WoodsJ Albert Schultz
May 22, 2002·Journal of the American Society for Mass Spectrometry·Alexei Gapeev, Robert C Dunbar
Jul 20, 2002·Trends in Neurosciences·Claudio SotoLaurence Anderes
Oct 5, 2002·Disease Markers·W Hayes McDonald, John R Yates
Oct 24, 2002·Journal of the American Chemical Society·E James PeterssonDennis A Dougherty
Feb 20, 2003·Protein Science : a Publication of the Protein Society·B David Silverman
Apr 29, 2003·Journal of Proteome Research·Amina S WoodsRoy A Wise
Oct 1, 1995·Journal of the American Society for Mass Spectrometry·P Lecchi, L K Pannell

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Citations

Mar 19, 2011·Journal of Molecular Neuroscience : MN·Alexander O Tarakanov, Kjell G Fuxe
Oct 5, 2013·Journal of the American Society for Mass Spectrometry·Shelley N Jackson, Amina S Woods
Feb 8, 2005·Journal of the American Society for Mass Spectrometry·Shelley N JacksonJ Albert Schultz
Nov 11, 2006·Journal of the American Society for Mass Spectrometry·Peran TerrierWilliam Buchmann
Sep 29, 2007·Journal of the American Society for Mass Spectrometry·Peran TerrierWilliam Buchmann
Jun 21, 2008·Journal of the American Society for Mass Spectrometry·Sheng YinJoseph A Loo
Jul 29, 2008·Journal of the American Society for Mass Spectrometry·Shelley N JacksonAmina S Woods
Feb 19, 2010·Journal of the American Society for Mass Spectrometry·Sheng Yin, Joseph A Loo
Aug 9, 2005·Journal of Proteome Research·Amina S Woods, Sergi Ferré
Jan 7, 2006·Journal of Proteome Research·Shelley N JacksonAmina S Woods
Jun 27, 2008·Journal of Proteome Research·Amina S WoodsShelley N Jackson
Jul 2, 2008·Journal of Proteome Research·Amina S WoodsKjell Fuxe
Jul 28, 2009·The Journal of Biological Chemistry·Gemma NavarroRafael Franco
Apr 11, 2006·Journal of Proteome Research·Amina S WoodsToni Shippenberg
Dec 9, 2014·Expert Opinion on Therapeutic Targets·Kjell FuxeDasiel O Borroto-Escuela
Feb 23, 2010·Journal of Receptor and Signal Transduction Research·Peter Kovacic, Marilyn E Hall
Jul 16, 2011·Advanced Drug Delivery Reviews·Satoshi OhtakeTsutomu Arakawa
Jun 19, 2010·Protein Expression and Purification·Vedrana MarinXian-Min Yu
Mar 30, 2010·Archives of Biochemistry and Biophysics·Atsushi HiranoKentaro Shiraki
Aug 1, 2015·Protein Expression and Purification·Atsushi HiranoTomoshi Kameda
Aug 19, 2015·Protein Expression and Purification·Tsutomu ArakawaGlen Young
Nov 15, 2006·Journal of Mass Spectrometry : JMS·Alice DelvolvéFrançoise Fournier
Sep 12, 2006·Protein Science : a Publication of the Protein Society·Laura H LucasC Russell Middaugh
Nov 3, 2010·Journal of Molecular Recognition : JMR·Peter TimmermanDanièle Altschuh
Feb 5, 2011·Mass Spectrometry Reviews·Amanda M PalumboGavin E Reid
Jan 18, 2005·Journal of Theoretical Biology·Michael E Green
Sep 4, 2015·Analytical Chemistry·Amanda L Patrick, Nicolas C Polfer
Jun 29, 2004·Micron : the International Research and Review Journal for Microscopy·George HarauzChristophe Farès
Nov 18, 2005·Biochimica Et Biophysica Acta·Padmanava PradhanMichael E Green
Feb 16, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Yanqing Ma, Gongxuan Lu
Feb 5, 2008·International Journal of Pharmaceutics·Tsutomu ArakawaA Hajime Koyama
Nov 14, 2012·Chemical Reviews·A Subha Mahadevi, G Narahari Sastry

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