The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro

Biomaterials
M M Murray, Myron Spector

Abstract

Guided tissue regeneration of the ruptured anterior cruciate ligament (ACL) offers the potential benefits of retaining the complex footprints of the ACL and the proprioceptive nerve fibers of the tissue. For this approach to be successful, ACL cells must retain the ability to migrate into an adjacent regeneration template, or scaffold, after ligament rupture. Ruptured ACLs were obtained from the knees of four men, ages 25-35, at the time of ACL reconstruction. Explants of ACL tissue were taken from three locations along the longitudinal axis of the remnant: the rupture site, the middle of the remnant, and far from the rupture site. These three areas have been found to be distinct histologically, with the region far from the rupture site having a histologic appearance similar to the intact ligament. Explants from each area were cultured in conventional tissue culture dishes (2-D culture) and on porous collagen-glycosaminoglycan (CG) scaffolds. Two-dimensional outgrowth was measured 3 times a week, and the 3-D explant/scaffold constructs were examined at 1, 2, 3 and 4 weeks to assess outgrowth of cells into the scaffold. The cell number density and expression of a-smooth muscle actin (SMA) were determined at each time point. The ...Continue Reading

References

Nov 1, 1992·The American Journal of Sports Medicine·G A PalettaR F Warren
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I V YannasG F Murphy
Mar 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A FaryniarzM Spector
Mar 12, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M M Murray, M Spector
Oct 29, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M M MurrayM Spector

❮ Previous
Next ❯

Citations

Feb 8, 2006·Annals of Biomedical Engineering·Eileen GentlemanEric A Nauman
Jul 25, 2013·Nature Reviews. Rheumatology·Frank Barry, Mary Murphy
Jan 21, 2011·Tissue Engineering. Part a·Andre F SteinertRyan M Porter
Feb 11, 2010·Tissue Engineering. Part B, Reviews·Patrick Vavken, Martha M Murray
Jul 21, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Dawn HastreiterMyron Spector
May 25, 2010·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Shan-Ling HsuSavio Ly Woo
Feb 17, 2007·American Journal of Physical Medicine & Rehabilitation·Chia-Hsin ChenZong-Ping Luo
Sep 4, 2008·Journal of Biomedical Materials Research. Part a·Claire M TierneyFergal J O'Brien
Feb 16, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K P SpindlerJ M Davidson
Feb 3, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M M MurrayA Steinert
Aug 23, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Paul F GratzerJ Michael Lee
Jul 3, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha Meaney Murray, Braden C Fleming
Jun 9, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Patrick VavkenMartha M Murray
Feb 27, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Patrick VavkenMartha M Murray
Jun 6, 2013·Journal of Biomedical Materials Research. Part a·Natalie L LeongDavid R McAllister
Nov 6, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley N MastrangeloMartha M Murray
Sep 20, 2006·Biomaterials·Derek M DoroskiJohnna S Temenoff
Jan 17, 2003·The Orthopedic Clinics of North America·Paul P WeitzelDavid L Kaplan
Sep 16, 2004·Journal of Biomedical Materials Research. Part a·Kevin G CornwellGeorge D Pins
Oct 13, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha M MurraySusan A Connolly
Mar 29, 2014·Journal of Biomedical Materials Research. Part a·Po-Yang ChenLynn L H Huang
Jul 27, 2007·Connective Tissue Research·Pen-Hsiu Grace ChaoJeannette Chloë Bulinski
Oct 12, 2010·Orthopaedics & Traumatology, Surgery & Research : OTSR·C LöcherbachB Sonnery-Cottet
Aug 13, 2014·The Knee·Bertrand Sonnery-CottetUNKNOWN French Arthroscopic Society
Dec 17, 2010·The Journal of Bone and Joint Surgery. American Volume·Louay FallouhKazuhisa Takahashi
Nov 24, 2016·Regenerative Medicine·Paulos Y MengsteabCato T Laurencin
Aug 6, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Arnulf PascherMartha Meaney Murray
Dec 10, 2008·Clinics in Sports Medicine·Martha M Murray
Jun 14, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gabriel S PerroneMartha M Murray
Aug 6, 2013·The American Journal of Sports Medicine·Bruce Reider
Sep 17, 2020·Biotechnology Letters·Qiao Chen, Youbin Wang
Jun 5, 2018·Applied Bionics and Biomechanics·M MarieswaranDinesh Kalyanasundaram
Aug 30, 2020·International Journal of Molecular Sciences·Alexander Yu GerasimenkoOlga E Glukhova
Dec 4, 2004·Clinical Orthopaedics and Related Research·Christopher H EvansPaul D Robbins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
M M MurrayMyron Spector
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Martha Meaney MurrayDavid Zurakowski
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
M Meaney MurrayMyron Spector
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Martha Meaney MurraySusan A Connolly
© 2021 Meta ULC. All rights reserved