The minimally effective dose of sucrose for procedural pain relief in neonates: a randomized controlled trial

BMC Pediatrics
Bonnie J StevensShirine Riahi

Abstract

Orally administered sucrose is effective and safe in reducing pain intensity during single, tissue-damaging procedures in neonates, and is commonly recommended in neonatal pain guidelines. However, there is wide variability in sucrose doses examined in research, and more than a 20-fold variation across neonatal care settings. The aim of this study was to determine the minimally effective dose of 24% sucrose for reducing pain in hospitalized neonates undergoing a single skin-breaking heel lance procedure. A total of 245 neonates from 4 Canadian tertiary neonatal intensive care units (NICUs), born between 24 and 42 weeks gestational age (GA), were prospectively randomized to receive one of three doses of 24% sucrose, plus non-nutritive sucking/pacifier, 2 min before a routine heel lance: 0.1 ml (Group 1; n = 81), 0.5 ml (Group 2; n = 81), or 1.0 ml (Group 3; n = 83). The primary outcome was pain intensity measured at 30 and 60 s following the heel lance, using the Premature Infant Pain Profile-Revised (PIPP-R). The secondary outcome was the incidence of adverse events. Analysis of covariance models, adjusting for GA and study site examined between group differences in pain intensity across intervention groups. There was no differ...Continue Reading

Associated Clinical Trials

May 9, 2014·Bonnie Stevens

References

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Citations

Nov 26, 2019·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Hsiang-Ping WuJen-Jiuan Liaw
Jan 3, 2020·Pediatric Research·Christopher McPhersonTerrie E Inder
Jun 6, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Böer-Auer, R Fölster-Holst
Jun 18, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Bilge Tanyeri-BayraktarGülsüm Güzel Kıran
Mar 11, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Somashekhar NimbalkarArchana Nimbalkar
Feb 23, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Annalisa PassarielloPaolo Giliberti
Feb 20, 2020·Pain Reports·Stefan J Friedrichsdorf, Liesbet Goubert
Dec 1, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Christopher McPhersonZachary Vesoulis
Dec 19, 2020·Der Schmerz·Stefan J Friedrichsdorf, Liesbet Goubert
Jan 23, 2021·Neonatal Network : NN·Manal KassabKhitam I Mohammad
Feb 17, 2021·Acta Anaesthesiologica Scandinavica·Miikka TervonenOuti Peltoniemi

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