The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms

Anesthesia and Analgesia
Albert WonEdmond I Eger

Abstract

The Meyer-Overton hypothesis predicts that anesthetic potency correlates inversely with lipophilicity; e.g., MAC times the olive oil/gas partition coefficient equals a constant of approximately 1.82 +/- 0.56 atm (mean +/- sd) for conventional inhaled anesthetics. MAC is the minimum alveolar concentration of anesthetic required to eliminate movement in response to a noxious stimulus in 50% of subjects. In contrast to conventional inhaled anesthetics, MAC times the olive oil/gas partition coefficient for normal alcohols from methanol through octanol equals a constant one tenth as large as that for conventional inhaled anesthetics. The alcohol (C-OH) group causes a great affinity of alcohols to water, and the C-OH may tether the alcohol at the hydrophobic-hydrophilic interface where anesthetics are thought to act. We hypothesized that the position of the C-OH group determined potency, perhaps by governing the maximum extent to which the acyl portion of the molecule might extend into a hydrophobic phase. Using the same reasoning, we added studies of ketones with similar numbers of carbon atoms between the C=O group and the terminal methyl group. The results for both alcohols and ketones showed the predicted correlation, but the cor...Continue Reading

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Citations

Oct 25, 2003·Anesthesiology·Anupama WadhwaDaniel I Sessler
Jul 12, 2008·International Anesthesiology Clinics·Stuart A Forman, Victor A Chin
Sep 23, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Justin H BoothHenry M Spotnitz
Sep 12, 2007·Journal of Pharmaceutical Sciences·Michael H AbrahamStacy Payne
Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Robert J Brosnan
Oct 26, 2007·Anesthesia and Analgesia·James G Bovill

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