The minimum peptides of IGF-1 and substance P protect vestibular hair cells against neomycin ototoxicity

Acta Oto-laryngologica
Shuhei YoshidaHiroshi Yamashita

Abstract

Our data indicate that SSSR and SSSR + FGLM-NH2 protect sensory hair cells against neomycin-induced death in the vestibular epithelium. In addition, the results show that SSSR and FGLM-NH2 can be used as protective molecules against aminoglycoside ototoxicity. This study investigated the role of the peptides SSSR and SSSR + FGLM-NH2 in mammalian vestibular hair cell death induced by aminoglycoside. Cultured utricles from mature CBA/N mice were used in this study. The cultured utricles were assigned to five groups (control group, neomycin group, neomycin + SSSR group, neomycin + FGLM-NH2 group, and neomycin + SSSR + FGLM-NH2 group). Aat 24 h after exposure to neomycin, the hair cells were labeled immunohistochemically, and the rate of survival of vestibular hair cells was evaluated using a fluorescence microscope. The rate of survival of vestibular hair cells was significantly higher in the neomycin + SSSR and neomycin + SSSR + FGLM-NH2 groups than in the neomycin group. The results suggest that SSSR could protect hair cells against aminoglycoside ototoxicity.

References

Dec 7, 2000·Journal of Neuroscience Research·V LevresseL E Heasley
Oct 7, 2004·Hearing Research·Isabel Varela-NietoYolanda Leon
Sep 29, 2006·Hearing Research·Kazuma SugaharaLisa L Cunningham
Aug 17, 2011·Frontiers in Molecular Neuroscience·Silvia Murillo-CuestaIsabel Varela-Nieto
Sep 4, 2012·Neuroscience Letters·Hideki ToyotaHiroshi Yamashita

❮ Previous
Next ❯

Citations

Jan 10, 2018·Frontiers in Aging Neuroscience·Lourdes Rodríguez-de la RosaIsabel Varela-Nieto
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Yanyan DingRenjie Chai
May 14, 2021·Archives of Toxicology·Luoying JiangYingzi He

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.