PMID: 9166304May 1, 1997Paper

The minimum single oral metronidazole dose for treating trichomoniasis: a randomized, blinded study

Obstetrics and Gynecology
M R SpenceJ L Smith

Abstract

To identify the minimum effective single oral dose of metronidazole for trichomoniasis. Women attending an inner-city sexually transmitted disease clinic who had Trichomonas vaginalis vaginitis diagnosed by microscopy were recruited for this randomized, double-blind study. Subjects were given a 0.5-, 1-, 1.5-, or 2-g single oral dose of metronidazole, taken under direct observation. Demographic information, symptoms, and clinical findings were collected from patient interviews, and physical examinations were conducted at the time of enrollment and at the follow-up visit. The primary outcome measure was treatment success at the follow-up visit, established by negative culture and microscopy. Three (1.8%) of the 167 women enrolled were excluded because of vomiting after taking metronidazole, and 66 (40%) of the 164 remaining subjects did not return for the follow-up visit. No associations were found between the proportion of subjects lost to follow-up and the characteristics of these subjects across assignment groups. The treatment success ratio was highest in subjects who received the 1.5-g dose (23, 85%), followed by the 2-g (16, 84%), 1-g (18, 62%), and the 0.5-g dose (8, 35%). A single 1.5-g dose of metronidazole has efficacy...Continue Reading

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Citations

Sep 17, 2003·Cell Research·Rebecca L DunneJacqueline A Upcroft
May 17, 2013·Sexually Transmitted Diseases·Patricia KissingerDavid H Martin
Mar 23, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Patricia KissingerDavid H Martin
Apr 23, 2013·Sexually Transmitted Infections·Patricia Kissinger, Alys Adamski
May 3, 2001·Enfermedades infecciosas y microbiología clínica·F VázquezV Palacio
Aug 9, 2003·The Journal of Pharmacy and Pharmacology·Sanaa A El-Gizawy, Nagwa I Aglan
Mar 1, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J T Núñez, G Gómez
Aug 6, 2015·BMC Infectious Diseases·Patricia Kissinger
May 1, 2015·Current Infectious Disease Reports·Patricia Kissinger
Jan 3, 2019·Sexually Transmitted Diseases·Megan Clare Craig-KuhnPatricia Kissinger
May 5, 2000·The Cochrane Database of Systematic Reviews·A M Gülmezoglu, F Forna
Sep 25, 2019·Medical Sciences : Open Access Journal·Aruna Kumari DivakaruniSrinivas Divakaruni
Feb 15, 2018·Antimicrobial Agents and Chemotherapy·Arindam P GhoshJane R Schwebke
Jun 14, 2003·The Cochrane Database of Systematic Reviews·F Forna, A M Gülmezoglu
Dec 2, 1998·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·K Patel
Aug 2, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Koichiro WadaShingo Yamamoto

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