The mirage of impairing drug concentration thresholds: a rationale for zero tolerance per se driving under the influence of drugs laws

Journal of Analytical Toxicology
Gary M ReisfieldRobert L DuPont

Abstract

Motor vehicle crashes are a leading cause of morbidity and mortality in the United States. Drivers with measurable quantities of potentially impairing illicit or prescription drugs in their body fluids are multiple times more likely to be involved in motor vehicle crashes than those without such drugs in their bodies. Drug-related impairment, however, cannot be inferred solely on the basis of the presence of drugs in biological fluids. Thus, for more than a quarter century, there has been a search for drug blood concentrations that are the equivalent of the 0.08 g/dL threshold for alcohol-impaired driving in the United States. We suggest that such equivalents are a mirage, and cannot be determined due to variable drug tolerance, lack of consistent relationships between drug blood concentrations and impairment, innumerable drug combinations and multiple other factors. Thus, while the idea of determining impairing drug concentrations is attractive, it is ultimately unattainable, and withholding drugged driving legislation pending the acquisition of such data is tantamount to a plan for inaction with regard to an important and growing public health and safety problem. We propose specific legislation to address alcohol- and drug-im...Continue Reading

References

Feb 1, 1985·Accident; Analysis and Prevention·A F Williams
Jun 5, 2003·Journal of Pain and Symptom Management·David A FishbainRenee Steele Rosomoff
Sep 11, 2003·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·T M RiceJ F Kraus
Oct 7, 2003·Journal of Pain and Symptom Management·Robert N JamisonNathaniel P Katz
Dec 3, 2003·The American Journal of Hospice & Palliative Care·George R Wilson, Gary M Reisfield
Jun 1, 2005·Forensic Science International : Synergy·Marc AugsburgerPatrice Mangin
Jun 16, 2007·European Addiction Research·Andjela BaewertGabriele Fischer
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catharine A WinstanleyEric J Nestler
Apr 17, 2008·British Journal of Pharmacology·M J Christie
Dec 31, 2008·Accident; Analysis and Prevention·Karoliina K OjaniemiAini I Ostamo
Apr 28, 2009·Accident; Analysis and Prevention·Ingebjørg GustavsenJørgen G Bramness
Jun 2, 2009·Frontiers in Bioscience (Landmark Edition)·Hiroshi Ueda, Mutsumi Ueda
Jun 15, 2010·Traffic Injury Prevention·Douglas J Beirness, Erin E Beasley
Jan 21, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Tharaka DassanayakeAlison Jones
May 7, 2011·Drug and Alcohol Review·Stefanie Y Leung

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Citations

Oct 1, 2013·Accident; Analysis and Prevention·Guohua LiQixuan Chen
Oct 2, 2012·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·Robert B VoasStephen K Talpins
Dec 3, 2014·Forensic Science International : Synergy·Vigdis VindenesHallvard Gjerde
Mar 5, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Naren Gunja
Jun 13, 2015·Traffic Injury Prevention·Ed WoodPhillip Drum
Feb 19, 2016·Traffic Injury Prevention·Fabrício Souza PeliçãoBruno Spinosa De Martinis
Jan 1, 2013·Journal of Drug Education·Melinda W PilkintonD Lee McCluskey
May 15, 2016·Journal of Safety Research·Ed Wood, Stacy Salomonsen-Sautel
Dec 1, 2014·Injury Epidemiology·Kristin WongGuohua Li
May 17, 2014·Drug and Alcohol Dependence·Stacy Salomonsen-SautelChristian Hopfer
Aug 20, 2016·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Mary A Celeste
Feb 19, 2013·Drug and Alcohol Dependence·Robert B VoasBrenda A Miller
Nov 5, 2016·Drug and Alcohol Dependence·Tara Marie Watson, Robert E Mann
Oct 15, 2014·Journal of Pharmacy Practice·Nicholas Sigona, Karl G Williams
Apr 23, 2013·Addiction·Eduardo Romano, Robin A Pollini
Aug 23, 2012·Clinical Chemistry·Alain G Verstraete
May 23, 2020·Substance Use & Misuse·Wade R BiasuttiRussell C Callaghan
Aug 17, 2020·Journal of Analytical Toxicology·Timothy P RohrigNicholas B Tiscione
Aug 17, 2020·American Journal of Industrial Medicine·John Howard, Jamie Osborne
May 12, 2017·Substance Abuse Treatment, Prevention, and Policy·Inmaculada FierroF Javier Álvarez

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