The missing effect of human recombinant Bone Morphogenetic Proteins BMP-2 and BMP-7 in surgical treatment of aseptic forearm nonunion

Injury
Christian von RüdenJan Friederichs

Abstract

In this cohort study, the surgical revision concept of open compression plating and autologous bone grafting with and without additional application of BMP for treatment of aseptic ulna and/or radius shaft nonunion was evaluated. The purpose was to evaluate the clinical and radiological outcome, and to determine any difference in osseous healing, range of time between revision surgery and bone healing, and postoperative complications between the cohort groups. Between 01/2005 and 03/2015, a prospective, randomised, controlled cohort study was performed in a Level I Trauma Centre. Forty-nine patients were treated with the diagnosis of aseptic diaphyseal ulnar and/or radial shaft nonunion using compression plating and autologous bone grafting. Additional biological augmentation using BMP-2 or BMP-7 was performed in 24 patients. Clinical and radiological follow-up was performed six weeks, three and six months after revision surgery in accordance to the system by Anderson. The study group consisted of 38 men and 11 women with a median age of 44 years (range 19-77). Twenty-four out of 49 patients obtained compression plating either with autologous iliac crest bone grafting (11/24 patients) or cancellous bone grafting (13/24 patients...Continue Reading

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Jul 2, 2015·The Bone & Joint Journal·M PapanagiotouK N Malizos

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Citations

Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Howa BegamAbhijit Chanda
Feb 22, 2018·Der Unfallchirurg·C HierholzerC von Rüden
Dec 15, 2018·The Journal of the American Academy of Orthopaedic Surgeons·Benjamin C TaylorTaleed El-Sabawi
Jun 17, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Catharina ChiariReinhard Windhager

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