PMID: 2126192May 1, 1990Paper

The "missing" mouse plasmacytoma (MPC) associated translocation T(15;16) occurs repeatedly in new MPC induction systems

Genes, Chromosomes & Cancer
F WienerG Klein

Abstract

A reciprocal translocation between chromosomes 15 and 16 has been detected in seven murine plasmacytomas induced by a combination of pristane and Abelson virus. Six of the tumors were induced in a new, unconventional experimental system based on transfer of uninfected or Abelson virus infected bone marrow and spleen cells, respectively, into pristane treated mice. All six tumors were of donor type. The seventh tumor appeared in a conventional pristane + Abelson virus treated mouse. This tumor was unusual in carrying both the 15;16 variant translocation and the typical 12;15 translocation, in the same tumor cells. In the new 15;16 variant, the breakpoint of chromosome 15 was at the interphase of the D2/3 sub-bands, as in mouse plasmacytomas with the previously well-known typical 12;15 and variant 6;15 translocations. The breakpoint on chromosome 16 was mapped to band 16B1, corresponding to the presumed cytogenetic site of the Ig-lambda gene. In three of the seven tumors with the 15;16 translocation, the derivative chromosome 15 had undergone a duplication, a feature that has not been previously encountered in the MPC-associated 12;15 and 6;15 translocation carriers. The reciprocal derivative chromosome 16 was lost from one of th...Continue Reading

References

Nov 15, 1990·International Journal of Cancer. Journal International Du Cancer·H SugiyamaG Klein
Aug 15, 1989·International Journal of Cancer. Journal International Du Cancer·S SilvaG Klein
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P D FahrlanderG Klein
Jan 12, 1972·Nature: New Biology·H C Wang, S Fedoroff
Jan 1, 1973·Chromosoma·M N Nesbitt, U Francke
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·F WienerH Bazin
Jan 1, 1982·Human Genetics·J RybakM Freeman
Sep 1, 1982·Cancer Genetics and Cytogenetics·F GilbertH Schlesinger

❮ Previous
Next ❯

Citations

Nov 14, 2007·The Journal of Experimental Medicine·Alexander L KovalchukMichael Potter
Aug 22, 2008·Postgraduate Medical Journal·G BradyP J Farrell
May 10, 1991·International Journal of Cancer. Journal International Du Cancer·H SugiyamaG Klein
Sep 9, 1991·International Journal of Cancer. Journal International Du Cancer·S SilvaG Klein
Jul 4, 2006·DNA Repair·Siegfried Janz
Jun 21, 2006·DNA Repair·Shyam Unniraman, David G Schatz
Jun 1, 1992·Psychological Reports·G D Zimet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.