The mitochondria in diabetic heart failure: from pathogenesis to therapeutic promise

Antioxidants & Redox Signaling
Joel D Schilling

Abstract

Diabetes is an important risk factor for the development of heart failure (HF). Given the increasing prevalence of diabetes in the population, strategies are needed to reduce the burden of HF in these patients. Diabetes is associated with several pathologic findings in the heart including dysregulated metabolism, lipid accumulation, oxidative stress, and inflammation. Emerging evidence suggests that mitochondrial dysfunction may be a central mediator of these pathologic responses. The development of therapeutic approaches targeting mitochondrial biology holds promise for the management of HF in diabetic patients. Despite significant data implicating mitochondrial pathology in diabetic cardiomyopathy, the optimal pharmacologic approach to improve mitochondrial function remains undefined. Detailed mechanistic studies coupled with more robust clinical phenotyping will be necessary to develop novel approaches to improve cardiac function in diabetes. Moreover, understanding the interplay between diabetes and other cardiac stressors (hypertension, ischemia, and valvular disease) will be of the utmost importance for clinical translation of scientific discoveries made in this field.

References

Oct 21, 1992·Molecular and Cellular Biochemistry·N S DhallaH Rupp
Dec 1, 1995·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F J SchmitzH Reinauer
Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F DjouadiD P Kelly
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsP Sleight
Jan 11, 2000·Circulation Research·A FrustaciP Anversa
Feb 1, 2002·Journal of Hypertension·Giovanni de SimoneRichard B Devereux
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brian N FinckDaniel P Kelly
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Laura L ListenbergerJean E Schaffer
Oct 9, 2003·The Journal of Laboratory and Clinical Medicine·Yakup AliciguzelUmit Karayalcin
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Gregory A NicholsJonathan B Brown
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saumya SharmaHeinrich Taegtmeyer
Nov 16, 2004·Lancet·Andrew J MurrayKieran Clarke
Mar 17, 2005·JAMA : the Journal of the American Medical Association·Eva LonnUNKNOWN HOPE and HOPE-TOO Trial Investigators
Jun 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Victoria J AdlamIvan A Sammut
Jul 26, 2005·Acta Pharmacologica Sinica·Loren E WoldJun Ren
Feb 7, 2006·Journal of the American College of Cardiology·Pilar HerreroRobert J Gropler
Mar 3, 2006·The Journal of Clinical Investigation·Brian N Finck, Daniel P Kelly
Jul 11, 2006·The American Journal of Medicine·Aaron M FromVéronique L Roger
Nov 30, 2006·Current Heart Failure Reports·Jerry D Estep, David Aguilar
Mar 17, 2007·Circulation Research·John YangDaniel P Kelly
May 19, 2007·Antioxidants & Redox Signaling·Yasuo Ido
Sep 1, 2007·BMJ : British Medical Journal·Dean T EurichJeffrey A Johnson
Feb 8, 2008·The New England Journal of Medicine·Mayank B Patel, Ashok Bhalla
Jun 3, 2008·Journal of Lipid Research·Tae-Sik ParkIra J Goldberg
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Jul 3, 2008·American Journal of Physiology. Endocrinology and Metabolism·Muhammad A Abdul-GhaniRalph A DeFronzo
Dec 19, 2008·The New England Journal of Medicine·William DuckworthUNKNOWN VADT Investigators
Mar 12, 2009·Current Opinion in Lipidology·Carles Cantó, Johan Auwerx
Sep 26, 2009·The Journal of Biological Chemistry·Li LiuIra J Goldberg

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Citations

Mar 27, 2015·Antioxidants & Redox Signaling·Vera B Schrauwen-HinderlingPatrick Schrauwen
Jan 8, 2016·Journal of Molecular and Cellular Cardiology·Qiangrong Liang, Satoru Kobayashi
Sep 20, 2016·Oxidative Medicine and Cellular Longevity·Angélica Ruiz-RamírezMohammed El-Hafidi
Feb 18, 2018·Fundamental & Clinical Pharmacology·Nair AnupamaKozhiparambil Gopalan Raghu
Mar 28, 2020·Journal of Clinical Medicine·Giampaolo MorcianoPaolo Pinton
Nov 9, 2017·Molecular Medicine Reports·Xiangting GaoShaohua Zhu
Jan 11, 2017·Journal of Biomedical Science·Ting-Wei LeeYi-Jen Chen
Mar 7, 2020·Frontiers in Cardiovascular Medicine·Nina Kaludercic, Fabio Di Lisa
May 25, 2020·Heart Failure Reviews·Upendra KaulT R Raghu
Mar 27, 2020·Frontiers in Physiology·Larissa VetterFelix T Kurz
Oct 8, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Quincy A HathawayJohn M Hollander
Jan 1, 2018·Nuclear Receptor Research·Qinglin Yang, Qinqiang Long
Dec 21, 2019·Experimental & Molecular Medicine·Jessica N PeoplesJennifer Q Kwong
Sep 19, 2018·Journal of Physiology and Biochemistry·Jiayu DiaoMengjie Chen
Jul 1, 2016·Clinical Science·Miguel A AonSteven J Sollott
May 26, 2018·International Journal of Vascular Medicine·Anderson Kiyoshi KagaAna Angélica Henrique Fernandes
Dec 29, 2020·Frontiers in Physiology·Satoru KobayashiQiangrong Liang
Jul 19, 2019·Molecular Therapy. Nucleic Acids·Huaping LiDao Wen Wang
Jan 6, 2021·Npj Aging and Mechanisms of Disease·Miguel A AonSteven J Sollott
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Daniela RamacciniMichelle L Matter
Oct 15, 2020·International Journal of Molecular Sciences·Micaela GliozziVincenzo Mollace
Oct 2, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Julieta Diaz-JuarezJorge Suarez
Apr 9, 2021·Frontiers in Cell and Developmental Biology·Kai-Lieh LinTsu-Kung Lin
Apr 17, 2021·Journal of Diabetes Research·Xiu WangWeina Hu
Jul 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Min YangXue-Zhi Wang
Jul 12, 2016·Journal of Proteome Research·D Brian FosterBrian O'Rourke
Aug 21, 2021·International Journal of General Medicine·Chan Li, Zhaoya Liu

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Methods Mentioned

BETA
transgenic

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