The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo

Cell Reports
Cristina MammucariRosario Rizzuto

Abstract

Muscle atrophy contributes to the poor prognosis of many pathophysiological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca(2+)], which control aerobic metabolism, cell death, and survival pathways. We investigated in vivo the effects of mitochondrial Ca(2+) homeostasis in skeletal muscle function and trophism by overexpressing or silencing the mitochondrial calcium uniporter (MCU). The results demonstrate that in both developing and adult muscles, MCU-dependent mitochondrial Ca(2+) uptake has a marked trophic effect that does not depend on aerobic control but impinges on two major hypertrophic pathways of skeletal muscle, PGC-1α4 and IGF1-Akt/PKB. In addition, MCU overexpression protects from denervation-induced atrophy. These data reveal a novel Ca(2+)-dependent organelle-to-nucleus signaling route that links mitochondrial function to the control of muscle mass and may represent a possible pharmacological target in conditions of muscle loss.

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Citations

Jan 23, 2016·Frontiers in Physiology·Vanina Romanello, Marco Sandri
Apr 22, 2015·Biochimica Et Biophysica Acta·Diego De StefaniRosario Rizzuto
Mar 13, 2016·Biochimica Et Biophysica Acta·Cristina MammucariRosario Rizzuto
Aug 20, 2015·Nature Reviews. Molecular Cell Biology·Kimberli J Kamer, Vamsi K Mootha
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Jun 13, 2016·European Biophysics Journal : EBJ·Roberta PeruzzoLuigi Leanza
May 6, 2016·Annual Review of Biochemistry·Diego De StefaniTullio Pozzan
Mar 24, 2016·Journal of Experimental Botany·Stephan WagnerIldikò Szabò
Sep 16, 2016·Oxidative Medicine and Cellular Longevity·Andrea Del CampoMaria Florencia Tevy
Oct 4, 2016·Trends in Biochemical Sciences·Anna RaffaelloRosario Rizzuto
Dec 20, 2016·The Journal of Physiology·Jennifer Q Kwong
Mar 10, 2017·Nature Reviews. Cardiology·Camila Lopez-CrisostoSergio Lavandero
Nov 9, 2016·Scientific Reports·Julien PrudentGermain Gillet
Apr 29, 2016·American Journal of Physiology. Cell Physiology·Bong Sook JhunJin O-Uchi
Apr 26, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hiroaki EshimaYutaka Kano
Dec 3, 2015·World Journal of Biological Chemistry·Jaime Santo-DomingoUmberto De Marchi
Jan 11, 2018·The Journal of Physiology·Daniela M Arduino, Fabiana Perocchi
Nov 15, 2018·Physiological Reviews·Lars LarssonMarco Sandri
Nov 16, 2018·British Journal of Pharmacology·Luigi LeanzaIldiko Szabo
Mar 29, 2019·The Journal of Physiology·Yuho KimBrian Glancy
May 4, 2016·EMBO Molecular Medicine·Anna TosattoCristina Mammucari
Oct 5, 2019·Oxidative Medicine and Cellular Longevity·Gaia GherardiCristina Mammucari
Sep 27, 2019·Acta Neuropsychiatrica·Anila VenugopalBalachandar Vellingiri
Oct 21, 2015·Oncotarget·Laura PietrangeloFeliciano Protasi
Mar 30, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Linlin GuA Brent Carter
Sep 28, 2017·Oxidative Medicine and Cellular Longevity·Hojun LeeSeung-Jun Choi
Mar 16, 2018·Pflügers Archiv : European journal of physiology·Cristina MammucariRosario Rizzuto
May 5, 2018·Cell Death and Differentiation·Maria PatronDiego De Stefani
Nov 19, 2019·Oxidative Medicine and Cellular Longevity·Veronica GranatieroRosario Rizzuto
Jul 24, 2020·Cellular and Molecular Neurobiology·Rodrigo G Mira, Waldo Cerpa
Jul 26, 2017·Frontiers in Oncology·Cristina MammucariRosario Rizzuto
Aug 10, 2017·American Journal of Physiology. Endocrinology and Metabolism·Lauren E WrightRosario Rizzuto
Jun 19, 2018·Frontiers in Physiology·Sander A J VerbruggeHenning Wackerhage
Mar 15, 2019·Journal of Neurotrauma·Zachary A GrahamChristopher P Cardozo
Aug 10, 2020·Life Science Alliance·Melissa Js MacEwenYasemin Sancak

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