The mitochondrial death/life regulator in apoptosis and necrosis

Annual Review of Physiology
G KroemerM Resche-Rigon

Abstract

Both physiological cell death (apoptosis) and, in some cases, accidental cell death (necrosis) involve a two-step process. At a first level, numerous physiological and some pathological stimuli trigger an increase in mitochondrial membrane permeability. The mitochondria release apoptogenic factors through the outer membrane and dissipate the electrochemical gradient of the inner membrane. Mitochondrial permeability transition (PT) involves a dynamic multiprotein complex formed in the contact site between the inner and outer mitochondrial membranes. The PT complex can function as a sensor for stress and damage, as well as for certain signals connected to receptors. Inhibition of PT by pharmacological intervention on mitochondrial structures or mitochondrial expression of the apoptosis-inhibitory oncoprotein Bcl-2 prevents cell death, suggesting that PT is a rate-limiting event of the death process. At a second level, the consequences of mitochondrial dysfunction (collapse of the mitochondrial inner transmembrane potential, uncoupling of the respiratory chain, hyperproduction of superoxide anions, disruption of mitochondrial biogenesis, outflow of matrix calcium and glutathione, and release of soluble intermembrane proteins) enta...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M W McEneryS H Snyder
Jun 15, 1992·FEBS Letters·K M BroekemeierD R Pfeiffer
Dec 1, 1991·Journal of Molecular and Cellular Cardiology·W NazarethM Crompton
Dec 1, 1993·Journal of Molecular and Cellular Cardiology·E J Griffiths, A P Halestrap
Oct 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G KroemerB Mignotte
Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W SedlakS J Korsmeyer
Apr 27, 1995·Nature·S ShimizuY Tsujimoto
Jan 1, 1995·Advances in Immunology·G Kroemer
Mar 3, 1995·The Journal of Biological Chemistry·D R PfeifferW L Erdahl
Mar 1, 1995·The American Journal of Physiology·J G PastorinoJ L Farber
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L VayssiereB Mignotte
Dec 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H M MehendaleL R Curtis
Jan 28, 1993·Nature·M D JacobsonM C Raff
Jun 1, 1996·The Journal of Cell Biology·M D JacobsenM C Raff
Jun 1, 1996·The Journal of Cell Biology·M WeilM C Raff
Apr 1, 1996·The Journal of Experimental Medicine·N ZamzamiG Kroemer
Sep 1, 1996·The American Journal of Physiology·C D Bortner, J A Cidlowski
Oct 1, 1996·The Journal of Experimental Medicine·S A SusinG Kroemer
Oct 1, 1996·Neuroscience·N A SimonianJ T Coyle
Nov 1, 1996·Circulation Research·H Fliss, D Gattinger
Nov 15, 1996·Cell·H G WangJ C Reed
Nov 22, 1996·The Journal of Biological Chemistry·J G PastorinoJ L Farber

❮ Previous
Next ❯

Citations

Mar 10, 2001·Journal of Cellular Physiology·M ZauggM A Siddiqui
Feb 13, 2002·Electrophoresis·Michael FountoulakisLaura Suter
Jan 22, 2000·Arthritis and Rheumatism·S R TewC W Archer
Aug 31, 2001·Journal of Cellular Biochemistry·E MontiM B Gariboldi
Jul 13, 2002·Journal of Cellular Physiology·Luigi RavagnanGuido Kroemer
Sep 5, 2002·The Journal of Pathology·Shawn Patrick GroganPierre Mainil-Varlet
Jun 22, 2000·Archives of Biochemistry and Biophysics·S YangA M Diehl
May 18, 2000·Biochemical and Biophysical Research Communications·A KoundourisM J Carter
Oct 12, 2001·Biochemical and Biophysical Research Communications·S TakanoS Tsuchiya
Apr 26, 2001·Cell Biology International·B J SoltysR S Gupta
Jun 16, 2001·Cell Biology International·M E Jones, L M Schwartz
Aug 13, 2002·Cell Biology International·Enzo Ottaviani, Davide Malagoli
Dec 26, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L XiangY B Kalin Zhang
Nov 21, 2008·Archives of Toxicology·Zuzana CervinkováZdenek Drahota
May 20, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Jean-Luc MorettiZeynep Burak
Nov 4, 2008·Journal of Bone and Mineral Metabolism·Tae Wook NamYong Keun Kim
Apr 22, 2005·Apoptosis : an International Journal on Programmed Cell Death·N AndolloJ Aréchaga
Sep 1, 2005·Apoptosis : an International Journal on Programmed Cell Death·R AutelliF M Baccino
May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·Jeong-Yeh YangClifton A Baile
Apr 17, 2008·Apoptosis : an International Journal on Programmed Cell Death·W S ChaiB Y Chen
Jul 16, 2008·Apoptosis : an International Journal on Programmed Cell Death·Devon J ShedlockDavid B Weiner
Jun 13, 2009·Apoptosis : an International Journal on Programmed Cell Death·Chi-Hung LinHung-Jeng Liu
Aug 6, 2009·Apoptosis : an International Journal on Programmed Cell Death·Fang HeTong Wang
Feb 13, 2010·Apoptosis : an International Journal on Programmed Cell Death·Luong Cong ThucTetsunori Saikawa
Sep 22, 2006·Biotechnology Letters·Kim C O'ConnorMohamed Al-Rubeai
Jul 5, 2013·Cardiovascular Drugs and Therapy·Francesco OnoratiGiuseppe Faggian
Jan 13, 2009·Cell Biology and Toxicology·Blanca Eugenia Farfán LabonneMaría Concepción Gutiérrez-Ruíz
Nov 13, 2008·Cytotechnology·Nyaradzo T Mukwena, Mohamed Al-Rubeai
Dec 4, 2008·Investigational New Drugs·Daniéli GerhardtChristianne Salbego
Sep 17, 2005·Journal of Bioenergetics and Biomembranes·Hossein Ardehali
Jul 19, 2006·Journal of Bioenergetics and Biomembranes·Konstantin BelosludtsevGalina D Mironova
Feb 13, 2007·Journal of Bioenergetics and Biomembranes·Dao M Nguyen, Mustafa Hussain

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy
ICE
electron microscopy

Related Concepts

Related Feeds

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis