The mitochondrial genome of the sea anemone Metridium senile (Cnidaria): introns, a paucity of tRNA genes, and a near-standard genetic code.

Genetics
C T BeagleyD R Wolstenholme

Abstract

The circular, 17,443 nucleotide-pair mitochondrial (mt) DNA molecule of the sea anemone, Metridium senile (class Anthozoa, phylum Cnidaria) is presented. This molecule contains genes for 13 energy pathway proteins and two ribosomal (r) RNAs but, relative to other metazoan mtDNAs, has two unique features: only two transfer RNAs (tRNA(f-Met) and tRNA(Trp)) are encoded, and the cytochrome c oxidase subunit I (COI) and NADH dehydrogenase subunit 5 (ND5) genes each include a group I intron. The COI intron encodes a putative homing endonuclease, and the ND5 intron contains the molecule's ND1 and ND3 genes. Most of the unusual characteristics of other metazoan mtDNAs are not found in M. senile mtDNA: unorthodox translation initiation codons and partial translation termination codons are absent, the use of TGA to specify tryptophan is the only genetic code modification, and both encoded tRNAs have primary and secondary structures closely resembling those of standard tRNAs. Also, with regard to size and secondary structure potential, the mt-s-rRNA and mt-1-rRNA have the least deviation from Escherichia coli 16S and 23S rRNAs of all known metazoan mt-rRNAs. These observations indicate that most of the genetic variations previously report...Continue Reading

References

Jan 1, 1976·Annual Review of Biochemistry·A Rich, U L RajBhandary
Nov 8, 1979·Nature·B G BarrellJ Drouin
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K BuzzoD R Wolstenholme
Jan 1, 1979·Progress in Nucleic Acid Research and Molecular Biology·R P Singhal, P A Fallis
Dec 1, 1992·Current Opinion in Genetics & Development·D R Wolstenholme
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D BridgeL W Buss
Jan 1, 1992·Annual Review of Cell Biology·A DietrichL Maréchal-Drouard
Jan 1, 1991·Annual Review of Cell Biology·D A Clayton
Jan 11, 1990·Nucleic Acids Research·A E PritchardD J Cummings
Jan 1, 1989·Nucleic Acids Research·M SprinzlR Zeidler
Jan 1, 1989·Methods in Enzymology·M Zuker
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L ColleauxB Dujon
Jul 20, 1988·Journal of Molecular Biology·H T JacobsA Farquharson
Jan 1, 1988·Nucleic Acids Research·R R Gutell, G E Fox
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D R WolstenholmeJ A Wahleithner
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B G BarrellI G Young
Oct 1, 1981·Cell·M J BibbD A Clayton
May 11, 1995·Nature·G A Pont-KingdonG D Clark-Walker
Oct 1, 1994·Journal of Molecular Evolution·J Ramón ValverdeR Garesse

❮ Previous
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Citations

Feb 26, 2000·Annual Review of Genetics·B F LangG Burger
Mar 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Aubrey D N J de Grey
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kevin G HelfenbeinJeffrey L Boore
Aug 13, 2004·Molecular Biology and Evolution·Daniel PapillonYannick Le Parco
Sep 1, 2004·Molecular Phylogenetics and Evolution·Iñaki Ruiz-TrilloJeffrey L Boore
Jan 11, 2007·Journal of Molecular Evolution·F SinnigerJ Pawlowski
May 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephen L DellaportaBernd Schierwater
Jan 24, 2008·PloS One·Yvonne VallèsJeffrey L Boore
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mónica MedinaJeffrey L Boore
Aug 30, 2005·Systematic Biology·Dennis V Lavrov, B Franz Lang
Dec 1, 2004·Annual Review of Genetics·Michael W GrayGertraud Burger
Jun 30, 2006·Toxicon : Official Journal of the International Society on Toxinology·Pradip K BandyopadhyayDavid R Wolstenholme
Oct 29, 2002·Current Biology : CB·B F LangG Burger
May 3, 2000·Genetics·Y NoguchiR Ueshima
Nov 28, 2002·Molecular Ecology·T L ShearerG Wörheide
Jan 23, 1999·Current Opinion in Genetics & Development·J L Boore, W M Brown
Feb 8, 2005·Journal of Molecular Evolution·Jonathan SwireAustin Burt
Sep 16, 2006·BMC Evolutionary Biology·Chagai RotDorothée Huchon
May 15, 2008·Marine Biotechnology·Chienhsun ChenChaolun Allen Chen
Nov 28, 2020·Scientific Reports·Isabela G L SeiblitzMarcelo V Kitahara
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gertraud BurgerB Franz Lang
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·K L AdamsJ D Palmer
Apr 2, 1999·Nucleic Acids Research·J L Boore
Dec 23, 1999·Current Opinion in Genetics & Development·M W Gray

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