The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

Trends in Neurosciences
Hirokazu Fukui, Carlos T Moraes

Abstract

Aging is the most important risk factor for common neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Aging in the central nervous system has been associated with elevated mutation load in mitochondrial DNA, defects in mitochondrial respiration and increased oxidative damage. These observations support a 'vicious cycle' theory which states that there is a feedback mechanism connecting these events in aging and age-associated neurodegeneration. Despite being an extremely attractive hypothesis, the bulk of the evidence supporting the mitochondrial vicious cycle model comes from pharmacological experiments in which the modes of mitochondrial enzyme inhibition are far from those observed in real life. Furthermore, recent in vivo evidence does not support this model. In this review, we focus on the relationship among the components of the putative vicious cycle, with particular emphasis on the role of mitochondrial defects on oxidative stress.

References

Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·K PrabhakaranG E Isom
Mar 6, 2003·American Journal of Human Genetics·Joelle M van der WaltJeffery M Vance
Nov 1, 2003·Science·Ted M Dawson, Valina L Dawson
Jan 7, 2004·Nature Reviews. Molecular Cell Biology·Michael R Lieber, Zarir E Karanjawala
Mar 24, 2004·Neuroscience Letters·Christian MawrinKnut Dietzmann
May 28, 2004·Nature·Aleksandra TrifunovicNils-Göran Larsson
Jul 2, 2004·Journal of Neurochemistry·Armen V Gyulkhandanyan, Peter S Pennefather
Sep 18, 2004·Trends in Neurosciences·Gustavo Barja
Dec 4, 2004·Biochimica Et Biophysica Acta·Carlos T MoraesAntoni Barrientos
Dec 23, 2004·Journal of Neural Transmission·Y TongW Song
Mar 1, 2005·Cell·Robert S BalabanToren Finkel
Apr 30, 2005·Nature Reviews. Genetics·Robert W Taylor, Doug M Turnbull
May 10, 2005·Science·Samuel E SchrinerPeter S Rabinovitch
Dec 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aleksandra TrifunovicNils-Göran Larsson
Mar 23, 2006·Nature Reviews. Neuroscience·Mark P Mattson, Tim Magnus
Jun 9, 2006·American Journal of Physiology. Cell Physiology·Flavia FontanesiAntoni Barrientos
Jun 20, 2006·Molecular and Cellular Biology·Francisca DiazCarlos T Moraes
Jul 11, 2006·Biochimica Et Biophysica Acta·Giorgio LenazAnnalisa Biondi
Feb 27, 2007·PLoS Genetics·Gregory C KujothTomas A Prolla
Apr 17, 2007·Molecular Cell·Elizabeth A VealBrian A Morgan
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Ping LiangManisha Patel
May 11, 2007·Acta Neurologica Scandinavica·Amos D Korczyn
Jun 21, 2007·PloS One·Simon MelovAshley I Bush
Jul 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nagendra Yadava, David G Nicholls
Jul 11, 2007·Current Opinion in Neurology·Albert Y Hung, Michael A Schwarzschild
Aug 19, 2007·Nature Reviews. Molecular Cell Biology·Marco GiorgioPier Giuseppe Pelicci

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Citations

Apr 30, 2015·Oxidative Medicine and Cellular Longevity·Bosch-Morell FranciscoNavea Amparo
May 28, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D SpeijerR Szklarczyk
May 28, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ian J HoltThomas B L Kirkwood
May 6, 2014·Integrative and Comparative Biology·Geoffrey E Hill
Sep 23, 2014·Protein Expression and Purification·Vaishali Sharma ChakrabartiVito Calderone
Feb 21, 2009·Rinshō shinkeigaku = Clinical neurology·Osamu Onodera
Dec 20, 2008·Human Molecular Genetics·Hirokazu Fukui, Carlos T Moraes
Mar 24, 2009·The Journal of Biological Chemistry·Akiko MaedaKrzysztof Palczewski
Sep 5, 2009·Cellular and Molecular Life Sciences : CMLS·Jérôme Lapointe, Siegfried Hekimi
Jan 26, 2010·Antioxidants & Redox Signaling·Ines Batinić-HaberleIvan Spasojević
Feb 17, 2010·Antioxidants & Redox Signaling·Renata SantosEmmanuel Lesuisse
Feb 17, 2010·Brain : a Journal of Neurology·Andrey Y AbramovDouglass M Turnbull
Feb 24, 2010·Journal of Neurotrauma·Lesley K GilmerStephen W Scheff
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrei G VlassenkoMark A Mintun
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ludmila A VolobouevaRona G Giffard
Oct 30, 2010·Integrative and Comparative Biology·Kaitlyn N LewisRochelle Buffenstein
Apr 2, 2011·The Journal of Biological Chemistry·Yi WenShao-Hua Yang
Feb 24, 2012·Human Molecular Genetics·Lloye M DillonCarlos T Moraes
Oct 12, 2012·PloS One·Ai-Ling LinTimothy Q Duong
Dec 7, 2011·Acta Neuropathologica·Mariusz Karbowski, Albert Neutzner
Jan 26, 2010·Antioxidants & Redox Signaling·Orly WeinrebMoussa B H Youdim
Nov 30, 2011·Antioxidants & Redox Signaling·Rommy von Bernhardi, Jaime Eugenín
Dec 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Stelvio SestiniLuigi Mansi
Jul 8, 2011·Human Genetics·Germaine EscamesDarío Acuña-Castroviejo
Apr 8, 2009·Biogerontology·Pamela Boon Li PunBarry Halliwell
Feb 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amanda CrawfordDominic P Geraghty
Jul 3, 2013·Molecular Neurobiology·Ashraf VirmaniSyed Ali
Dec 14, 2011·Free Radical Research·Renato X SantosPaula I Moreira
Oct 29, 2008·FEBS Letters·Félix Hernández, Jesús Avila
Mar 23, 2013·Mechanisms of Ageing and Development·Andriy Khobta, Bernd Epe
Jan 8, 2013·Biological Psychiatry·Yvette I Sheline, Marcus E Raichle
May 19, 2012·Free Radical Biology & Medicine·María MoránCristina Ugalde
Mar 20, 2012·Neurobiology of Disease·M E BreuerJ A M Smeitink

❮ Previous
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