The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis

Laboratory Investigation; a Journal of Technical Methods and Pathology
Marie-Lise LacombeUwe Schlattner

Abstract

Mitochondrial nucleoside diphosphate kinase (NDPK-D; synonyms: NME4, NM23-H4) represents the major mitochondrial NDP kinase. The homohexameric complex emerged as a protein with multiple functions in bioenergetics and phospholipid signaling. It occurs at different but precise mitochondrial locations and can affect among other mitochondrial shapes and dynamics, as well as the specific elimination of defective mitochondria or cells via mitophagy or apoptosis. With these various functions in cell homeostasis, NDPK-D/NME4 adds to the group of so-called moonlighting (or gene sharing) proteins.

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Citations

Feb 17, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mathieu BoissanMarie-Lise Lacombe
Sep 20, 2020·International Journal of Molecular Sciences·Florian GeorgescauldAlain Dautant
Feb 28, 2019·American Journal of Physiology. Cell Physiology·Kati MadoTuuli Kaambre
Aug 23, 2020·International Journal of Molecular Sciences·Kevin AdamTony Hunter
Jul 24, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ying-Jie ZhaoJing Li

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Methods Mentioned

BETA
imaging techniques
GTPase

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