The mitochondrial permeability transition as a target for neuroprotection.

Journal of Bioenergetics and Biomembranes
Bruce S KristalRobert M Friedlander

Abstract

Mitochondria serve as checkpoints and amplifiers on cell death pathways. In the central nervous system, mitochondrial involvement seems essential for normal expression of cell death phenotypes, and interference with these pathways thus seems a reasonable approach to neuroprotection. We have been involved in examining the potential involvement of the mitochondrial permeability transition (mPT) as one of several possible mechanisms by which mitochondria may be drawn into these death cascades. This possibility, though still controversial, is supported by evidence that factors that may stimulate mPT induction are associated with some forms of cell death (e.g., in stroke) and are modulated by diseases of the central nervous system (e.g., Huntington's). Evidence of neuroprotection seen with compounds such as N -Met-Val cyclosporine also support this possibility.

Citations

Jan 31, 2008·Journal of Translational Medicine·Kaushik Dilip Deb, Kanchan Sarda
May 10, 2011·Neurosurgery·Yi ZhangRobert M Friedlander
Oct 2, 2008·Journal of Neurosurgery·Jimmi HattonByron Young
Jul 6, 2010·Cellular and Molecular Life Sciences : CMLS·Andrzej Galat, Jacqueline Bua
Jan 26, 2016·Journal of Neuroscience Methods·Nicolas K KhattarRobert M Friedlander
May 17, 2011·Experimental Gerontology·Arivazhagan Palaniyappan, Rajesh Alphonse
Feb 24, 2016·Biochimica Et Biophysica Acta·Lucia BiasuttoMario Zoratti
Mar 25, 2006·Stem Cells·Vanessa J HallMiodrag Stojkovic
May 3, 2007·Journal of Neurochemistry·Ying-jun GuanRobert M Friedlander
Sep 27, 2007·CNS Drug Reviews·Pierre Etienne Chabrier, Michel Auguet
Dec 29, 2004·Biochimica Et Biophysica Acta·Mario ZorattiUmberto De Marchi
Nov 2, 2014·Journal of Bioenergetics and Biomembranes·Shyam GajavelliRoss M Bullock
Oct 27, 2009·Neurochemistry International·Carine ClerenM Flint Beal
Oct 13, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Martin CourLaurent Argaud
Jun 26, 2010·Current Protocols in Neuroscience·Tibor Kristian
May 3, 2006·The FEBS Journal·Paolo BernardiMichael A Forte
Sep 12, 2007·Journal of Neuroscience Research·Lucian SoaneGary Fiskum
Jan 24, 2007·Physiological Reviews·Guido KroemerCatherine Brenner
Aug 7, 2010·Expert Opinion on Pharmacotherapy·Alex TselisRobert P Lisak
Mar 8, 2007·Neurochemical Research·Irina G Gazaryan, Abraham M Brown
Apr 15, 2020·Experimental Neurology·Epiphani C SimmonsRick G Schnellmann

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