The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart.

Journal of the Society for Gynecologic Investigation
Aaron K OlsonJ L Segar

Abstract

Protein kinase B (Akt) and the mitogen-activated protein kinases (MAPKs) mediate hypertrophy in the adult heart, although their importance in the developing heart is poorly understood. The goal of the current study was to determine if volume loading the fetal heart resulting from chronic anemia affects regulation of Akt and the MAPKs and if this response is developmentally regulated. Anemia was created by 7 days of isovolumic hemorrhage beginning at 101 days (early GA) or 129 days (late GA) gestational age (GA) in fetal sheep (term = 145 days), following which protein levels of total and active Akt, extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun NH2-terminal kinase (JNK), and p38 were determined in the right and left ventricle (RV and LV). RV protein-to-DNA ratios were also assessed. At both GAs, ventricular (RV + LV + septum) weight normalized to body weight was significantly increased in anemic fetuses. Anemia had no effect on expression of myocardial total or active Akt, JNK, or p38 at either GA. Levels of total ERK1/2 were also unchanged, although active ERK1/2 was significantly decreased in the late but not early GA anemic fetuses. Total JNK and total and active ERK1/2 and Akt were significantly greater in early...Continue Reading

References

Apr 29, 1972·The Veterinary Record·J J Jennings, J P Crowley
Nov 1, 1984·Hypertension·S OparilF J Clubb
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A BarberaK L Thornburg
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·P LiaoY Wang
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J L SegarT D Scholz
Feb 22, 2002·European Journal of Biochemistry·Shinri TamuraTakayasu Kobayashi
Apr 27, 2002·Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme·Shinri TamuraTakayasu Kobayashi
Nov 2, 2002·Circulation Research·Orlando F Bueno, Jeffery D Molkentin
Mar 11, 2003·The Journal of Physiology·N C SundgrenK L Thornburg
Aug 30, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nathan C SundgrenKent L Thornburg
Sep 16, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Judith H BurrellEugenie R Lumbers
Dec 5, 2003·Journal of Molecular and Cellular Cardiology·Qiangrong Liang, Jeffery D Molkentin
Jul 28, 2004·Journal of Molecular and Cellular Cardiology·Gavin Y OuditPeter H Backx
May 5, 2005·Genes & Development·Felix B EngelMark T Keating

❮ Previous
Next ❯

Citations

Jul 11, 2012·Clinical and Experimental Pharmacology & Physiology·Kimberley C W WangJanna L Morrison
Feb 18, 2011·Canadian Journal of Physiology and Pharmacology·Sonnet S JonkerJeffrey L Segar
Aug 25, 2009·Experimental Physiology·Sonnet S JonkerKent L Thornburg
Dec 7, 2007·Aesthetic Plastic Surgery·B S Atiyeh, S N Hayek
Oct 30, 2012·Experimental Physiology·Jeffrey L SegarThomas D Scholz
Mar 27, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeremy SandgrenJeffrey L Segar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Aaron K OlsonThomas D Scholz
American Journal of Physiology. Endocrinology and Metabolism
E R LumbersJulie A Owens
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Christopher E MascioJ L Segar
© 2022 Meta ULC. All rights reserved