PMID: 4571328Apr 1, 1973

The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule

The Journal of Experimental Medicine
J AnderssonO Lüderitz

Abstract

Lipopolysaccharides with different structure, isolated from different mutant strains of Escherichia coli and Salmonella bacteria, and chemical degradation products of these lipopolysaccharides have been employed to investigate which part of the lipopolysaccharide molecule exerts mitogenic effects on bone marrow-derived mouse lymphocytes. Within the structure of lipopolysaccharide consisting of lipid A, a core polysaccharide, and the O-polysaccharide antigen, lipid A was found to be the mitogenic part. The mitogenic effect of lipid A, consisting of phosphorylated glucosamine disaccharide units with ester- and amide-linked fatty acids, was lost after alkali treatment, which removes ester-linked fatty acids. Insertion of the lipid A portion of lipopolysaccharides into the lipid bilayer of the plasma membranes of bone marrow-derived lymphocytes is discussed as the initial mitogenic action.

References

Dec 4, 1972·European Journal of Biochemistry·K Reske, K Jann
Dec 1, 1972·European Journal of Immunology·W W Bullock, E Möller
Jan 12, 1971·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R B Taylor, G M Iverson
Aug 1, 1972·Cellular Immunology·J AnderssonO Sjöberg
Aug 1, 1972·European Journal of Immunology·J AnderssonG Möller
Jan 1, 1972·Transplantation Reviews·J AnderssonG Möller
Mar 1, 1971·European Journal of Biochemistry·C GalanosO Westphal
Jul 13, 1972·European Journal of Biochemistry·E T RietschelO Westphal
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Jun 1, 1969·European Journal of Biochemistry·C GalanosO Westphal

Citations

Nov 1, 1978·Die Naturwissenschaften·O LüderitzJ Weckesser
Jan 1, 1990·Archives of Virology·H P WeissH Becht
Jan 1, 1992·Cancer Immunology, Immunotherapy : CII·E KumazawaY Osada
Jul 1, 1976·Agents and Actions·T L Vischer
Apr 16, 1987·Journal of Immunological Methods·D U BellstedtK J Van der Merwe
Jun 3, 1991·Journal of Immunological Methods·P L Fiori, P Rappelli
Jan 1, 1979·Comparative Immunology, Microbiology and Infectious Diseases·J M KaneeneR K Anderson
Jan 1, 1981·Pharmacology & Therapeutics·O LüderitzE T Rietschel
Sep 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F OttoR Engelhardt
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Susanne BrixHanne Frøkiaer
Dec 1, 1996·FEMS Immunology and Medical Microbiology·O HolstE T Rietschel
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P WernetH G Kunkel
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·C BonaL Chedid
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B Weiss, L Sachs
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Z DintzisH M Dintzis
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C R RaetzK Takayama
Dec 1, 1973·The Journal of Experimental Medicine·I ScherK W Sell
Mar 1, 1974·The Journal of Experimental Medicine·C KolbE Weiler
Nov 1, 1974·The Journal of Experimental Medicine·D L RosenstreichA Nowotny
Jun 1, 1975·The Journal of Experimental Medicine·M D Jacobs, D C Morrison
Aug 1, 1975·The Journal of Experimental Medicine·F MelchersC Galanos
Oct 1, 1975·The Journal of Experimental Medicine·J L RyanP A Henkart
Sep 1, 1976·The Journal of Experimental Medicine·J L Ryan, P A Henkart
Jun 1, 1978·The Journal of Experimental Medicine·J AnderssonF Melchers
Mar 1, 1983·The Journal of Experimental Medicine·L HangF J Dixon
Nov 1, 1977·Microbiology and Immunology·M NakanoK Hisatsune
Jan 1, 1975·Scandinavian Journal of Immunology·A Coutinho, G Möller
Jan 1, 1978·Scandinavian Journal of Immunology·C I Smith, L Hammarström
May 16, 1978·European Journal of Biochemistry·D Männel, H Mayer
Jan 1, 1975·Transplantation Reviews·G Janossy, M F Greaves
Aug 1, 1976·The Journal of Clinical Investigation·J W Smith, B Kaijser
Jan 27, 2009·Critical Reviews in Immunology·Jeremy P McAleer, Anthony T Vella
Sep 1, 1975·Beiträge Zur Pathologie·N Freudenberg, U Häublein
Jul 1, 1975·Beiträge Zur Pathologie·N FreudenbergC Mittermayer
Dec 1, 1990·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·Y OhshimaW Roszkowski
May 23, 2014·Immunologic Research·Claire M Buchta, Gail A Bishop
Dec 1, 1986·Scandinavian Journal of Dental Research·T HofstadN Skaug
Feb 1, 1980·Scandinavian Journal of Dental Research·L BlomlöfP O Söder
Jan 1, 1981·Microbiology and Immunology·S NagaoA Tanaka
Jan 1, 1981·Microbiology and Immunology·S KurashigeS Mitsuhashi
Jan 1, 1980·Journal of Oral Pathology·C G DalyJ B Kieser
Jun 30, 1983·Annals of the New York Academy of Sciences·D M JacobsA J Rosenspire
Jan 1, 1982·Immunological Reviews·J P McKearnJ M Davie
Feb 1, 1978·Experimental Cell Research·W LernhardtF Melchers
Feb 1, 1992·Lupus·N A Granholm, T Cavallo
May 23, 1976·Biochemical and Biophysical Research Communications·W G Bessler, B P Ottenbreit
Jun 1, 1975·Journal of Dental Research·E HausmannN Weinfeld
Nov 1, 2007·European Journal of Immunology·F Melchers
Feb 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·G Möller
Sep 26, 1973·Nature: New Biology·G JanossyM F Greaves
Jan 1, 1985·Microbiology and Immunology·T Saito-TakiA Hasegawa
Feb 1, 1984·European Journal of Immunology·Y KumazawaT Shiba
Mar 1, 1979·European Journal of Immunology·Y NaotH Ginsburg
Jan 1, 1981·Journal of Immunopharmacology·D M Jacobs
Jan 1, 1975·Immunological Communications·S H Hsu
Dec 6, 2017·World Journal of Microbiology & Biotechnology·Nina V EvseevaSergei Yu Shchyogolev
Jan 1, 1974·Immunological Communications·C BonaB Cinader
Jan 1, 1974·Scandinavian Journal of Immunology·A CoutinhoW Richter
May 1, 1977·European Journal of Immunology·A CoutinhoT Watanabe
Nov 1, 1977·CRC Critical Reviews in Toxicology·L J Berry
Jan 1, 1974·Immunological Communications·L ChedidC Bona
May 5, 2016·European Journal of Immunology·F Melchers
Oct 1, 1974·European Journal of Immunology·F Melchers, J Andersson
Aug 1, 1974·European Journal of Immunology·J Andersson, F Melchers
Aug 15, 1974·International Journal of Cancer. Journal International Du Cancer·J L McCoyB J Holiman
Jan 19, 2019·Scientific Reports·Faisal MinshawiStamatia Papoutsopoulou
Oct 1, 1982·European Journal of Immunology·J R HiernauxC Bona
Jan 1, 1982·Journal of Cellular Physiology. Supplement·F Melchers
Jun 1, 1976·European Journal of Immunology·F MelchersJ Sprent

Related Concepts

Antibody Formation
Antibody-Secreting Cells
B-Lymphocytes
Marrow
Bone Marrow Cells
DNA, Double-Stranded
Electrophoresis, Disc
Alkalescens-Dispar Group
Hemolytic Plaque Technique
IgM2

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.