The Mix family of homeobox genes--key regulators of mesendoderm formation during vertebrate development

Developmental Biology
Lloyd A PereiraAndrew G Elefanty

Abstract

The Mix/Bix family of paired-like homeobox genes encode evolutionarily conserved, sequence specific, DNA-binding transcription factors that have been implicated in the co-ordination of gene expression, axis formation and cell fate determination during gastrulation in vertebrates. When mutated, these genes give rise to dramatic phenotypes in amphibians, zebrafish and mice, that can be traced back to defects in the formation and specification of mesoderm and endoderm. We review here the biochemical properties of the Mix/Bix proteins and summarise genetic, molecular and embryological studies of Mix/Bix function in mesendoderm development. We emphasise recent data generated using embryonic stem cell differentiation systems that have provided important new insights into Mix/Bix function and the biological roles of these proteins in regulating the earliest phases of vertebrate development.

References

Jun 21, 1990·Nature·A J van den Eijnden-Van RaaijD Huylebroeck
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Nov 1, 1993·Genes & Development·D WilsonC Desplan
Jan 1, 1994·Annual Review of Biochemistry·W J GehringT Bürglin
Dec 1, 1995·Current Opinion in Cell Biology·G M Keller
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·D S WilsonC Desplan
Jul 1, 1997·Mechanisms of Development·M ArtingerK W Cho
Feb 7, 1998·The Journal of Biological Chemistry·V DanilovH Steinbeisser
Jul 4, 1998·Science·G L Henry, D A Melton
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P E MeadL I Zon
Sep 18, 1998·Mechanisms of Development·F V PealeM Bothwell
Aug 26, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L Dale, C M Jones
Sep 24, 1999·Mechanisms of Development·J J Pearce, M J Evans
Oct 26, 1999·Current Biology : CB·J Alexander, D Y Stainier
Nov 5, 1999·Developmental Biology·J AlexanderD Y Stainier
May 18, 2000·Biochemical and Biophysical Research Communications·T HirataT Hirano
Nov 21, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L RobbA G Elefanty
Jun 1, 2002·Science·Liliana Attisano, Jeffrey L Wrana
Jan 17, 2003·Cell Research·Guang Jin PanDuanqing Pei
Mar 6, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Deanna MohnMargaret H Baron
Mar 14, 2003·Nature·Ruedi Aebersold, Matthias Mann
Jul 11, 2003·Nature·Michael Levine, Robert Tjian
Aug 20, 2003·Development·Margarida TrindadeJames C Smith
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Alexander F Schier

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Citations

Sep 13, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Minoru TakasatoMelissa H Little
Mar 19, 2014·Gene Expression Patterns : GEP·Adam D Wolfe, Karen M Downs
Dec 15, 2015·Cytokine & Growth Factor Reviews·Valeria V OrlovaGudrun Valdimarsdottir
Aug 19, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Geng ChenQinghua Tao
Sep 23, 2008·BMC Evolutionary Biology·Görel SundströmDan Larhammar
Jul 20, 2010·BMC Genetics·Sumantra ChatterjeeThomas Lufkin
Aug 20, 2011·PLoS Genetics·Sylvain W Lapan, Peter W Reddien
Oct 14, 2003·PLoS Biology·Christian BraendleDavid L Stern
Aug 31, 2016·Nature Reviews. Nephrology·Melissa H LittleMinoru Takasato
Mar 24, 2021·Briefings in Functional Genomics·Daniela M FigielAndrew C Nelson

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