The mixed serotonin receptor agonist psilocybin reduces threat-induced modulation of amygdala connectivity

NeuroImage. Clinical
Rainer KraehenmannFranz X Vollenweider

Abstract

Stimulation of serotonergic neurotransmission by psilocybin has been shown to shift emotional biases away from negative towards positive stimuli. We have recently shown that reduced amygdala activity during threat processing might underlie psilocybin's effect on emotional processing. However, it is still not known whether psilocybin modulates bottom-up or top-down connectivity within the visual-limbic-prefrontal network underlying threat processing. We therefore analyzed our previous fMRI data using dynamic causal modeling and used Bayesian model selection to infer how psilocybin modulated effective connectivity within the visual-limbic-prefrontal network during threat processing. First, both placebo and psilocybin data were best explained by a model in which threat affect modulated bidirectional connections between the primary visual cortex, amygdala, and lateral prefrontal cortex. Second, psilocybin decreased the threat-induced modulation of top-down connectivity from the amygdala to primary visual cortex, speaking to a neural mechanism that might underlie putative shifts towards positive affect states after psilocybin administration. These findings may have important implications for the treatment of mood and anxiety disorders.

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Citations

Sep 30, 2016·Expert Review of Neurotherapeutics·Bas T H de VeenJudith R Homberg
Nov 24, 2017·Frontiers in Pharmacology·Rainer KraehenmannFranz X Vollenweider
Jan 20, 2017·Therapeutic Advances in Psychopharmacology·Ananya Mahapatra, Rishi Gupta
May 29, 2018·Journal of Psychopharmacology·Michelle S ThiessenAdele Lafrance
Nov 14, 2018·International Review of Psychiatry·Albert Garcia-Romeu, William A Richards
Apr 3, 2019·Reviews in the Neurosciences·Noemi Császár-NagyIstván Bókkon
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Sep 1, 2017·Journal of Psychopharmacology·R L Carhart-Harris, D J Nutt
Aug 1, 2018·Psychopharmacology·Frederick S BarrettRoland R Griffiths
Feb 12, 2020·Scientific Reports·Frederick S BarrettRoland R Griffiths
Feb 13, 2019·Psychological Medicine·Stephanie N DeCrossDaphne J Holt
Sep 16, 2020·Nature Reviews. Neuroscience·Franz X Vollenweider, Katrin H Preller
May 16, 2019·Journal of Psychopharmacology·Albert Garcia-RomeuMatthew W Johnson
Feb 23, 2020·Biomedicines·Candace R LewisFranz X Vollenweider
Sep 22, 2020·Expert Review of Neurotherapeutics·Hartej GillRoger S McIntyre
Aug 6, 2019·Journal of Affective Disorders·Silvia MuttoniChristopher John
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Jun 15, 2021·International Review of Psychiatry·Catherine I V BirdJames J H Rucker
Oct 5, 2021·Brain Connectivity·Ronald SladkyChristian Windischberger

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