Mar 21, 2020

The mKATP channels and PKC are involved in the cardioprotective effects of genistein on estrogen-deficient rat hearts exposed to ischemia/reperfusion: energetic study

Journal of Cardiovascular Pharmacology
Germán A ColaredaAlicia E Consolini

Abstract

Estrogenic deficiency is considered a risk for coronary disease in women. The phytoestrogen genistein could be a safe preventive strategy. The first aim of this work was to validate a model of cardiac stunning in which natural estrogenic deficiency rats, i.e adult young male (YM) and aged female (AgF), are compared to young female rats (YF). The second aim was to study whether the in vivo administration of genistein prevents the stunning in estrogenic deficiency rats. The third aim was to evaluate if in our estrogenic deficiency model exists a synergy between genistein and estradiol. The fourth aim was to characterize the underlying mechanisms of genistein. Stunning was induced by ischemia/reperfusion (I/R) in isolated hearts inside a calorimeter. The left ventricular pressure (P) and total heat rate (Ht) were simultaneosly measured, while diastolic contracture and muscle economy (P/Ht) were calculated. During R, P/Ht and P recovered less in AgF and YM than in YF rat hearts. Genistein via i.p. (GST-ip) improved P and P/Ht in AgF and YM, but not in YF. In YM, the cardioprotections of GST-ip and estradiol were synergistic. After ischemia GST-ip increased SR Ca leak causing diastolic contracture. The GST-ip cardioprotection neithe...Continue Reading

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Mentioned in this Paper

Muscle
Oestrogen Deficiency
Calcium Channel
Nitric Oxide Synthase
Woman
Protein Kinase C
Heart
Proto-Oncogene Proteins c-akt
In Vivo
Sarcoplasmic Reticulum Calcium-Transporting ATPase 3

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