The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism.

Current Topics in Microbiology and Immunology
A N Billin, D E Ayer

Abstract

Recent experiments suggest the existence of a transcriptional network that functions in parallel to the canonical Myc/Max/Mad transcriptional network. Unlike the Myc/Max/Mad network, our understanding of this network is still in its infancy. At the center of this network is a Max-like protein called Mlx; hence we have called this network the Mlx network. Like Max, Mix interacts with transcriptional repressors and transcriptional activators, namely the Mad family and the Mondo family, respectively. Similar to Max-containing heterodimers, Mlx-containing heterodimers recognize CACGTG E-box elements, suggesting that the transcriptional targets of these two networks may overlap. Supporting this hypothesis, we have observed genetic interactions between the Drosophila melanogaster orthologs of Myc and Mondo. In higher eukaryotes, two proteins, MondoA and MondoB/CHREBP/WBSCR14, constitute the Mondo family. At present little is known about the transcriptional targets of MondoA; however, pyruvate kinase is a putative target of MondoB/CHREBP/WBSCR14, suggesting a function for the Mondo family in glucose and/or lipid metabolism. Finally, unlike the predominant nuclear localization of Myc family proteins, both Mondo family members localize ...Continue Reading

Citations

Jun 3, 2016·Cell Structure and Function·Mai TaniguchiHiderou Yoshida
Feb 10, 2017·Cell Structure and Function·Mai Taniguchi, Hiderou Yoshida
Aug 9, 2018·The Journal of Biological Chemistry·Huabo WangEdward V Prochownik
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xuemei TongCraig B Thompson
Feb 18, 2011·Transcription·Mohan R KaadigeDonald E Ayer
Aug 16, 2006·Seminars in Cancer Biology·Peter J Hurlin, Jie Huang

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