PMID: 6159343Aug 1, 1980Paper

The mode of action of nanaomycin A in Gram-positive bacteria

The Journal of Antibiotics
H MarumoS Omura

Abstract

The mode of action of nanaomycin A on Gram-positive such as Staphylococcus aureaus, Bacillus cereus and Streptococcus faecalis was investigated. Nanaomycin A inhibited the biosyntheses of protein, DNA, RNA and cell-well peptidoglycan to a similar extent. It increased the oxygenous respiration of S. aureus cells at the minimal inhibitory concentration. The cells preincubated with nanaomycin A showed stimulation of proton influx after addition of N,N'-dicyclo-hexylcazrbodiimide, an inhibitor of Ca++, Mg++-ATPase. Nanaomycin A seems to interfere with the cytoplasmic or to inhibit coupling of oxidative phosphorylation, followed by secondary inhibitory effect on protein, nucleic acids and cell-wall peptidoglycan biosyntheses.

Citations

Dec 25, 2007·Nature Chemical Biology·Peter O KrutzikGarry P Nolan
Sep 14, 2010·Molecular Cancer Therapeutics·Dirk KuckJose L Medina-Franco

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