The mode of antibacterial action of the novel agent ZM240304 (D-arabino-2,3,4-tris(4-chlorobenzyl) pentane-1,5-diamine)

The Journal of Antimicrobial Chemotherapy
K Barrett-BeeJ Stawpert

Abstract

ZM240304 is an example of a new class of antibacterial agents that is active against experimental infections in animals. The compound was demonstrated to be a membrane-active compound that disrupted the outer membrane of Gram-negative organisms and allowed the leakage of periplasmic enzymes. Respiration was inhibited and cellular ATP levels were reduced, leading to cell death. The ability of the bacteria to take up small molecules such as amino acids and sugars was inhibited, probably by interference with inner membrane function.

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Bacterial Respiration (ASM)

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.