The model of pentylenetetrazol-induced status epilepticus in the immature rat: short- and long-term effects

Epilepsy Research
A Nehlig, A Pereira de Vasconcelos

Abstract

In order to assess acute, short and long-term effects of seizures in the immature rat brain, we studied the metabolic, circulatory and histopathological changes induced by pentylenetetrazol (PTZ) given at postnatal day 10 (P10) or 21 (P21). Seizures were induced by repetitive subconvulsive injections of PTZ given as a first dose of 40 mg/kg followed 10 min later by 20 mg/kg. Thereafter, rats received every 10 min additional injections of PTZ 10 mg/kg until the onset of status epilepticus. Local cerebral metabolic rates for glucose (LCMRglc) were measured both during the seizures in P10 and P21 rats and in the young adult animal at P60 by means of the quantitative 2-deoxyglucose technique. Rates of local cerebral blood flow (LCBF) were determined during the seizures by the iodoantipyrine technique. Short-term histological changes were assessed by acid fuchsin and hematoxylin-eosin staining and by HSP72 immunohistochemistry. At P10, LCMRglcs uniformly increased (38-400%) over control values during seizures. At P21, metabolic increases (39-181%) occurred only in 20% of the structures while LCMRglcs decreased in most cortical, hippocampal and sensory areas as well as in mammillary body, discrete thalamic nuclei and white matter are...Continue Reading

References

Mar 1, 1979·Early Human Development·J Dobbing, J Sands
Jan 1, 1979·Folia Psychiatrica Et Neurologica Japonica·T FujiwaraT Wada
Dec 1, 1992·Neuroscience Research·F MurakamiH Katsumaru
Nov 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·L VelisekR Schickerova
Feb 21, 1992·Brain Research. Developmental Brain Research·C E StafstromG L Holmes
Mar 20, 1992·Brain Research. Developmental Brain Research·L BômontA Nehlig
May 20, 1991·Brain Research. Developmental Brain Research·E F SperberS L Moshé
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A NehligS Boyet
Feb 1, 1986·Italian Journal of Neurological Sciences·F De RomanisS Ruggieri
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C MacNeill, R M Bryan
Nov 1, 1986·Pediatric Neurology·C S HornD L Hurst
Mar 1, 1985·Neuroscience·T L PazdernikS R Nelson
Sep 1, 1985·Annals of Neurology·G NevanderB K Siesjö
Jan 1, 1972·Epilepsia·E A Rodin
Jan 1, 1984·Acta Neuropathologica·R N AuerB K Siesjö
Feb 1, 1984·Annals of Neurology·J H EllenbergK B Nelson
Apr 16, 1984·Brain Research·M C Evans, B S Meldrum
Mar 1, 1984·Brain Research·B J AlbalaR Okada
Jan 14, 1994·Brain Research. Developmental Brain Research·D Chang, T Z Baram
Nov 1, 1994·Brain Research. Molecular Brain Research·A M PlanasE Rodríguez Farré
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A Pereira de VasconcelosA Nehlig

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Citations

Mar 29, 2001·Physiology & Behavior·I A KliouevaS A Chepurnov
Jun 24, 1998·Brain Research. Developmental Brain Research·A Pereira de VasconcelosA Nehlig
Aug 14, 1999·Brain Research. Developmental Brain Research·E F SperberP K Stanton
Sep 9, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·D A Hosford
Aug 9, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Linda K FriedmanRobert Keesey
Feb 6, 2008·Epilepsy & Behavior : E&B·Rama MagantiSteve Chung
Mar 24, 2016·Annals of the New York Academy of Sciences·Vassiliki Aroniadou-AnderjaskaMaria F M Braga
Nov 29, 2005·Seizure : the Journal of the British Epilepsy Association·H LiuJ Kaur
Sep 8, 2004·Brain Research. Developmental Brain Research·Javad TowfighiRobert C Vannucci
Jan 1, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M L Mamalyga, L M Mamalyga
Dec 25, 2019·Seizure : the Journal of the British Epilepsy Association·Richard J BurmanColin J Akerman

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