The moderating role of an oxytocin receptor gene polymorphism in the relation between unsupportive social interactions and coping profiles: implications for depression

Frontiers in Psychology
Opal A McInnisHymie Anisman

Abstract

Oxytocin is a hormone that is thought to influence prosocial behaviors and may be important in modulating responses to both positive and negative social interactions. Indeed, a single nucleotide polymorphism, rs53576, of the oxytocin receptor gene (OXTR) has been associated with decreased trust, empathy, optimism, and social support seeking, which are important components of coping with stressors. In the current study, conducted among undergraduate students (N = 225), it was shown that parental and peer social support was related to fewer depressive symptoms through elevated problem-focused coping and lower emotion-focused coping, and these effects were independent of the OXTR polymorphism. Unsupportive social interactions from parents were associated with more severe depressive symptoms through the greater use of emotion-focused coping, and this relation was moderated by the OXTR genotype. Specifically, individuals who carried the polymorphism on one or both of their alleles demonstrated increased emotion-focused coping following unsupportive responses compared to those without the polymorphism. Likewise, lower problem-focused coping mediated the relation between parental and peer unsupportive responses to depressive symptoms,...Continue Reading

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Citations

Aug 4, 2016·Frontiers in Human Neuroscience·Robyn J McQuaidHymie Anisman
Dec 9, 2016·Scientific Reports·Takayuki FujiiHaruto Takagishi
Feb 27, 2017·Stress : the International Journal on the Biology of Stress·Opal A McInnisHymie Anisman
May 9, 2019·European Archives of Psychiatry and Clinical Neuroscience·Laetitia J C A SmariusSusanne R de Rooij
Jun 13, 2021·Journal of Psychiatric Research·Jieting ZhangGianluca Esposito

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Methods Mentioned

BETA
electrophoresis
PCA

Software Mentioned

SPSS Statistics

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