The Modified Bushen Antai Recipe Upregulates Estrogen and Progesterone Receptors at the Maternal-Fetal Interface in Pregnant Rats with Mifepristone-Induced Pregnancy Loss

Evidence-based Complementary and Alternative Medicine : ECAM
Li SunJichun Tan

Abstract

The modified Bushen Antai recipe (BSAT) is a centuries-old traditional Chinese medicine that we use in our center as a therapy against pregnancy loss. Our study aimed to explore the potential benefit and mechanism of BSAT in pregnant rats with mifepristone-induced pregnancy loss. The signature compounds of the eight BSAT ingredients were analyzed by high-performance liquid chromatography (HPLC). The BSAT group (n = 8) was treated daily with 6.3 ml/kg BSAT from gestation day (D) 0.5 to 10.5 and once with 1.25 mg/kg mifepristone on D 10.5. Normal saline replaced BSAT in the model group (n = 8), and both BSAT and mifepristone in the control group (n = 8). Morphological and histological analyses were performed on D 13.5. BSAT contains eight medicinal ingredients including Cuscuta chinensis and Dipsacus asperoides. The HPLC analysis detected the signature compounds of seven medicinal ingredients in the extract. Embryo resorption rate in the BSAT group was significantly lower than that in the model group, although the number of surviving embryos was similar between the two groups. Hematoxylin and eosin (HE) staining suggested that the maximum cross-sectional area of the placenta and the area ratio of the placental labyrinth in the BS...Continue Reading

References

Oct 7, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G MakrydimasK H Nicolaides
Jan 28, 2006·The Journal of Physiology·A L FowdenM Constancia
Sep 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Liyin Zhu, Jeffrey W Pollard
May 12, 2009·Journal of Ethnopharmacology·Zhen-Guo LiuQi-Bing Mei
Dec 1, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·L SaraswatS Bhattacharya
May 14, 2010·The Cochrane Database of Systematic Reviews·Priscilla DevaseelanLesley Regan
Sep 13, 2011·Archives of Pharmacal Research·Burcu Caliskan ErgünErden Banoglu
Oct 28, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xia LiJian-Ping Li
May 18, 2012·The Cochrane Database of Systematic Reviews·Lu LiChi Chiu Wang
Dec 25, 2012·Contraception·Nathalie KappDalia Brahmi
Jun 21, 2013·BMC Complementary and Alternative Medicine·Meijie LiuDahong Ju
Nov 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yayi SunZhiying Hu
Jan 11, 2014·Journal of Biomedical Science·Xin LiRuijin Shao
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens
Nov 20, 2014·Human Reproduction Update·Bansari PatelSam Mesiano
Jan 23, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fadi Ghazi MirzaClaire Pexman-Fieth
Jan 26, 2016·American Journal of Reproductive Immunology : AJRI·Arpita S BhurkeMilan K Bagchi
Sep 7, 2016·JAMA : the Journal of the American Medical Association·Joel G RayAlison L Park
Sep 10, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Song YangXiangri Li
Oct 22, 2017·Journal of Ethnopharmacology·Zhifei FuXiumei Gao
Jan 10, 2018·Journal of Assisted Reproduction and Genetics·Luis Alejandro Arias-SosaMaribel Forero-Castro
Nov 20, 2018·The American Journal of Cardiology·Jaya BatraJoanna Chikwe

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
Reverse Transcription Polymerase Chain Reaction
PCR

Software Mentioned

Image pro plus ( IPP )
7500
Image J
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Ming-min ZhangKe-qin Zeng
Evidence-based Complementary and Alternative Medicine : ECAM
Hai-Wang WuJie Gao
Evidence-based Complementary and Alternative Medicine : ECAM
Juan GuiGuang-Ying Huang
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Weiliang SunJunming Guo
© 2022 Meta ULC. All rights reserved