The Modified Glasgow Prognostic Score and Survival in Colorectal Cancer: A Pooled Analysis of the Literature

Reviews on Recent Clinical Trials
F PetrelliAlberto Zaniboni

Abstract

It has been reported that the combination of inflammation parameters, such as albumin and C-reactive protein, in the modified Glasgow prognostic score (m-GPS) is a poor prognostic indicator in several malignancies. Here, we quantify the prognostic impact of this score and assess its value in colorectal cancer. A systematic review of electronic databases was conducted to identify publications exploring the association of m-GPS with outcome in colorectal cancer. Overall survival (OS) was the primary outcome, and cancer-specific survival (CSS), progression-free survival, and disease-free survival were secondary outcomes. Data from studies reporting a hazard ratio (HR) and 95% confidence interval (CI) were included in a metaanalysis. Pooled HRs were computed and weighted using generic inverse-variance and random effects modeling. All statistical tests were two-sided. Nine studies, which included a total of 2,227 patients, were included in the analysis. Overall, according to multivariate analysis, m-GPS≥1 was independently associated with an HR for OS of 1.69 (95% CI=1.4-2.04; P<0.00001), an effect observed in all stages of disease. Six studies including a total of 1,751 patients reported HR for CSS. Overall, a high m-GPS was associ...Continue Reading

Citations

Nov 7, 2019·Current Opinion in Supportive and Palliative Care·David HuiCarlos Eduardo Paiva
Jan 4, 2020·International Journal of Colorectal Disease·Shintaro HashimotoTakeshi Nagayasu
Apr 14, 2020·Cancer Management and Research·Chen ZhengXiang Zhao
Apr 20, 2020·International Journal of Colorectal Disease·Sung Chul LeeJung Kyong Shin
Apr 24, 2019·Nutrients·Hang Huong LingPei-Hung Chang
Jun 15, 2019·Journal of Translational Medicine·Juha P VäyrynenMarkus J Mäkinen
Nov 19, 2020·Cancer Management and Research·Yu-Yuan HanXiao-Dong Zhu

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