The modified glasgow prognostic score is an independent prognostic indicator in neoadjuvantly treated adenocarcinoma of the esophagogastric junction

Oncotarget
G JomrichS F Schoppmann

Abstract

The modified Glasgow Prognostic Score (mGPS) combines the indicators of decreased plasma albumin and elevated CRP. In a number of malignancies, elevated mGPS is associated with poor survival. Aim of this study was to investigate the prognostic role of mGPS in patients with neoadjuvantly treated adenocarcinomas of the esophagogastric junction 256 patients from a prospective database undergoing surgical resection after neoadjuvant treatment between 2003 and 2014 were evaluated. mGPS was scored as 0, 1, or 2 based on CRP (>1.0 mg/dl) and albumin (<35 g/L) from blood samples taken prior (preNT-mGPS) and after (postNT-mGPS) neoadjuvant therapy. Scores were correlated with clinicopathological patients' characteristics. From 155 Patients, sufficient data was available. Median follow-up was 63.8 months (33.3-89.5 months). In univariate analysis, Cox proportional hazard model shows significant shorter patients OS (p= 0.04) and DFS (p= 0.02) for increased postNT-mGPS, preNT-hypoalbuminemia (OS:p= 0.003; DFS:p= 0.002) and post-NT-CRP (OS:p= 0.03; DFS:p= 0.04). Elevated postNT-mGPS and preNT-hypoalbuminemia remained significant prognostic factors in multivariate analysis for OS (p= 0.02;p= 0.005,) and DFS (p= 0.02,p= 0.004) with tumor diff...Continue Reading

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Citations

Aug 18, 2018·Journal of Gastroenterology and Hepatology·Kensuke KudouYoshihiko Maehara
Feb 2, 2019·Annals of Surgical Oncology·Gerd JomrichSebastian F Schoppmann
Mar 30, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Gerd JomrichMartin Schindl
Nov 19, 2020·Cancer Management and Research·Yu-Yuan HanXiao-Dong Zhu

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