The modifying effect of selenium and vitamins A, C, and E on the genotoxicity induced by sunset yellow in male mice

Mutation Research
Hanaa M SayedM A Fahmy

Abstract

The use of food additives in various products is growing up. It has attracted the attention towards the possible correlation between the mutagenic potential of food additives and various human diseases. This work evaluated the protective role of selenium and vitamins A, C and E (selenium ACE)(1) against the genotoxic effects induced by a synthetic food additive, sunset yellow, in mice. Six groups were studied including two control groups (negative and positive control), two groups are given single dose of sunset yellow (either 0.325, 0.65 or 1.3mg/kg body weight(2) alone or with selenium ACE) and two groups are given sunset yellow daily for 1, 2 or 3 weeks (0.325mg/kg b.wt./day alone or with selenium ACE), respectively. The study examined the induction of sister chromatid exchanges (SCE's)(3) in bone-marrow cells, chromosomal aberration in somatic (bone-marrow) and germ cells (spermatocytes) after single and repeated oral treatment, and the induction of morphological sperm abnormalities. The results showed that sunset yellow had genotoxic effects as indicated by increased frequency of SCE's, by chromosomal aberrations in both somatic and germ cells, and by increased morphological sperm abnormalities and DNA fragmentation. The r...Continue Reading

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Citations

Apr 4, 2015·International Journal of Food Sciences and Nutrition·Rogerio Correa PeresDaniel Araki Ribeiro
Sep 14, 2018·Drug and Chemical Toxicology·Mohamed Yassin AliMohamed Fawzy Ramadan
Dec 30, 2016·Archives of Toxicology·Fazlullah KhanMohammad Abdollahi
Jul 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Márcio CarochoIsabel C F R Ferreira

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