The modular serine proteases of the complement cascade

Current Opinion in Structural Biology
Federico FornerisPiet Gros

Abstract

Modular serine proteases are central to the complement cascade of the mammalian humoral immune system. These proteases form protein complexes through multi-domain interactions to achieve their proteolytic activity. We review the structural insights into complement initiation by auto-activation of the hetero-tetrameric proteases of the large danger-recognition protein complexes, amplification and labelling of particles by the formation and activity of C3 convertases, and regulation by convertase dissociation and degradation to prevent 'bystander' damage to healthy host cells and tissues. The data reveal that complex formation and large domain-domain rearrangements underlie the proteolytic reactions of the complement cascade, which enables the host to recognize and clear invading microbes and host debris from its blood and fluids surrounding tissues.

References

Dec 1, 1992·Biochemistry·G RivasA P Minton
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J BoydG J Arlaud
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J TschoppJ Engel
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C J StrangV N Schumaker
Jun 21, 2001·Immunological Reviews·M D Kirkitadze, P N Barlow
May 30, 2002·Nature Reviews. Immunology·Teizo Fujita
Nov 5, 2002·Molecular Immunology·Gérard J ArlaudJuan Carlos Fontecilla-Camps
Nov 21, 2002·Biochemical Society Transactions·M K Pangburn, N Rawal
Jun 6, 2003·The Journal of Biological Chemistry·Lynn A GregoryChristine Gaboriaud
Jan 30, 2004·Biochemical Society Transactions·R B Sim, S A Tsiftsoglou
Jul 26, 2005·The Journal of Biological Chemistry·Péter GálPéter Závodszky
Jul 13, 2006·Journal of Molecular Biology·Folmer FredslundLars Sottrup-Jensen
Dec 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Noritaka NishidaTimothy A Springer
Feb 21, 2007·Nature Structural & Molecular Biology·Fin J MilderPiet Gros
May 10, 2007·The Journal of Biological Chemistry·László BeinrohrPéter Závodszky
Sep 5, 2007·Molecular Immunology·Gérard J ArlaudSthanam V L Narayana
Dec 8, 2007·Nature Reviews. Immunology·Piet GrosBert J C Janssen
Jan 16, 2009·Trends in Immunology·A P SjöbergA M Blom
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·J A Huntington
Aug 20, 2010·Nature Immunology·Daniel RicklinJohn D Lambris
Sep 2, 2010·Thrombosis and Haemostasis·Alvin E DavisPedro Mejia
Sep 21, 2010·The Journal of Clinical Investigation·Rubén Martínez-BarricarteSantiago Rodríguez de Córdoba
Jan 11, 2011·The EMBO Journal·Nick S LaursenGregers R Andersen
Feb 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tommi KajanderT Sakari Jokiranta
Feb 15, 2011·Nature Structural & Molecular Biology·Hugh P MorganJonathan P Hannan
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Martin AlcorloOscar Llorca
Aug 25, 2011·The Journal of Biological Chemistry·Dennis E Hourcade, Lynne M Mitchell

❮ Previous
Next ❯

Citations

Aug 13, 2013·Clinical & Developmental Immunology·Rosana Rosa Miranda CorrêaMarlene Antônia dos Reis
Nov 19, 2013·Clinical Proteomics·Mario NavarreteJohn A Wilkins
Aug 2, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Zhi-Gang ZhangYou-Qiang Song
Jun 24, 2014·Microbes and Infection·Fatima El AamriDaniel Padilla
Jul 19, 2014·Journal of Theoretical Biology·Dieter ArmbrusterJon Young
Jul 24, 2013·Current Opinion in Structural Biology·Panagiotis L Kastritis, Alexandre M J J Bonvin
May 21, 2013·The Journal of Allergy and Clinical Immunology·Yuko WatanabeShigeru Tsuchiya
Aug 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Umakhanth Venkatraman GirijaRussell Wallis
Oct 4, 2014·Frontiers in Immunology·Lakshmi Carmel WijeyewickremaRobert Neil Pike
Jul 15, 2016·Cell and Tissue Research·Liisa NissinenVeli-Matti Kähäri
Sep 27, 2016·Frontiers in Molecular Biosciences·Martina PalaminiFederico Forneris
Nov 2, 2016·Frontiers in Immunology·Mischa P KeizerTaco W Kuijpers
Jan 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jamal O M AlmitairiRussell Wallis
Jul 14, 2018·Proteomics·Beatriz MagalhãesRui Vitorino
Feb 15, 2018·Scientific Reports·Mathivanan ChinnarajNicola Pozzi
Jan 25, 2014·The Journal of Biological Chemistry·Shilpa GadwalMaria Sandkvist
Aug 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura Pérez-AlósPeter Garred
Feb 26, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ida JarlheltPeter Garred
Dec 1, 2014·Biophysics Reviews·Marni Williams, Richard Baxter
Jul 25, 2019·International Journal of Molecular Sciences·Pilvi RiihiläVeli-Matti Kähäri
Dec 5, 2019·International Neurourology Journal·Seung-Hoon Yang
Jun 24, 2021·British Journal of Pharmacology·Ulrich WenzelJörg Köhl
Oct 5, 2017·Journal of Medicinal Chemistry·Abishek IyerDavid P Fairlie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.