The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin--A biochemical study in rats subjected to experimental hyperlipidemia and obesity

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Padmanabhan Monika, Arumugam Geetha

Abstract

Obesity is a multifactorial disorder which is closely associated with hyperlipidemia. Avocados are edible fruits traditionally consumed for various health benefits including body weight reduction. To determine the hypolipidemic and anti-obesity effect of hydro-alcoholic fruit extract of avocado (HFEA) in rats fed with high fat diet (HFD). Male Sprague Dawley rats were divided into four groups. Groups 1 and 2 rats were fed with normal diet. Groups 3 and 4 rats were fed with HFD for 14 weeks. In addition, Groups 2 and 4 rats were co-administered with 100 mg/kg body weight of HFEA from 3rd week onwards. The HFEA was subjected to HPLC to quantify the major phytonutrients. Body mass index (BMI), adiposity index (ADI), total fat pad mass (TFP), blood lipid levels were determined in all the groups of rats. The mRNA expression of fatty acid synthase (FASN), lipoprotein lipase (LPL), fibroblast growth factor 21 (FGF21) and leptin was also assessed. HFEA was found to contain flavonoids: rutin-141.79, quercetin-5.25, luteolin-165, phenolic compounds: gallic acid-198.57, ellagic acid-238.22, vanillic acid-4.79 and phytosterols: betasitosterol-70, stigmasterol-12.5 (mg/100 g). HFEA reduced BMI, ADI, TFP, blood cholesterol, triglycerides, an...Continue Reading

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Citations

Apr 11, 2017·Phytotherapy Research : PTR·Jamshid TabeshpourHossein Hosseinzadeh
Sep 2, 2016·Hormone Molecular Biology and Clinical Investigation·Albert Pérez-MartíJoana Relat
Jun 11, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Vanessa Plasse RamosRejane Giacomelli Tavares
Apr 19, 2018·The Nurse Practitioner·Rosanne PruittAdam Carroll
Sep 26, 2019·Food & Function·Jianfeng LongZhaoping Li
Dec 24, 2018·Nutrients·Phiwayinkosi V DludlaSithandiwe E Mazibuko-Mbeje
Jan 15, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shifan TangYanfen Huang
Dec 10, 2020·Food Research International·Norma Julieta Salazar-LópezG A González-Aguilar

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