Abstract
Obesity is a multifactorial disorder which is closely associated with hyperlipidemia. Avocados are edible fruits traditionally consumed for various health benefits including body weight reduction. To determine the hypolipidemic and anti-obesity effect of hydro-alcoholic fruit extract of avocado (HFEA) in rats fed with high fat diet (HFD). Male Sprague Dawley rats were divided into four groups. Groups 1 and 2 rats were fed with normal diet. Groups 3 and 4 rats were fed with HFD for 14 weeks. In addition, Groups 2 and 4 rats were co-administered with 100 mg/kg body weight of HFEA from 3rd week onwards. The HFEA was subjected to HPLC to quantify the major phytonutrients. Body mass index (BMI), adiposity index (ADI), total fat pad mass (TFP), blood lipid levels were determined in all the groups of rats. The mRNA expression of fatty acid synthase (FASN), lipoprotein lipase (LPL), fibroblast growth factor 21 (FGF21) and leptin was also assessed. HFEA was found to contain flavonoids: rutin-141.79, quercetin-5.25, luteolin-165, phenolic compounds: gallic acid-198.57, ellagic acid-238.22, vanillic acid-4.79 and phytosterols: betasitosterol-70, stigmasterol-12.5 (mg/100 g). HFEA reduced BMI, ADI, TFP, blood cholesterol, triglycerides, an...Continue Reading
References
Jan 1, 1991·Journal of Clinical Epidemiology·D S Gray, K Fujioka
Jan 1, 1989·Free Radical Biology & Medicine·T Miyazawa
Dec 29, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·M KuchmakL Taylor
Oct 1, 1996·Journal of Biotechnology·L Lesage-MeessenM Asther
Jan 7, 2000·The American Journal of Medicine·M H Moghadasian, J J Frohlich
Jul 20, 2002·Trends in Genetics : TIG·Gudrun A Brockmann, Marianna R Bevova
Aug 8, 2002·Fitoterapia·O O AdeyemiO O Ogunti
Oct 29, 2004·Nutrition Reviews·Beth Carlton TohillBarbara J Rolls
Apr 12, 2005·Journal of Cardiovascular Pharmacology and Therapeutics·Eleni T BairaktariMoses S Elisaf
Sep 28, 2005·Diabetes·Janin BerndtMatthias Blüher
Oct 14, 2006·Molecular Nutrition & Food Research·Chin-Lin Hsu, Gow-Chin Yen
Mar 30, 2007·Diabetologia·X Yang, U Smith
Mar 11, 2008·Expert Review of Cardiovascular Therapy·Harold E BaysRobert R Henry
Jun 24, 2008·Chemico-biological Interactions·Aera JangCheorun Jo
Jul 1, 2008·Biochemical and Biophysical Research Communications·Jiyun AhnTaeyoul Ha
Sep 17, 2008·Biochemical Society Transactions·Chong Yew Tan, Antonio Vidal-Puig
Sep 30, 2008·Arquivos brasileiros de endocrinologia e metabologia·André F NascimentoAntonio C Cicogna
Nov 11, 2008·Current Cancer Drug Targets·Yong LinHan-Ming Shen
Aug 5, 2010·Diabetes·Ffolliott M FisherEleftheria Maratos-Flier
May 4, 2011·World Journal of Diabetes·Parul SinglaAnuj A Parkash
Sep 29, 2011·Circulation·Marc-Andre CornierUNKNOWN Council on the Kidney in Cardiovascular Disease, and Stroke Council
Jan 4, 2013·Nutrition Journal·Victor L FulgoniAdrienne J Davenport
May 15, 2013·Cell Metabolism·Zhuofeng LinXiaokun Li
Jun 19, 2013·BMC Complementary and Alternative Medicine·Salem S Al-RejaieMohamed M Hafez
Citations
Mar 8, 2017·PloS One·Nadine W SantosLucia M Zeoula
Apr 11, 2017·Phytotherapy Research : PTR·Jamshid TabeshpourHossein Hosseinzadeh
Dec 22, 2017·Molecular Nutrition & Food Research·Viviana SandovalJoana Relat
Feb 6, 2019·Food & Function·Hernán E VerónSebastian Torres
Sep 5, 2019·Antioxidants·Viviana SandovalJoana Relat
Sep 2, 2016·Hormone Molecular Biology and Clinical Investigation·Albert Pérez-MartíJoana Relat
Jun 11, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Vanessa Plasse RamosRejane Giacomelli Tavares
Sep 17, 2016·Advances in Nutrition·Inhae KangSoonkyu Chung
Apr 19, 2018·The Nurse Practitioner·Rosanne PruittAdam Carroll
Apr 30, 2020·Foods·Sotirios KiokiasVassiliki Oreopoulou
Sep 26, 2019·Food & Function·Jianfeng LongZhaoping Li
May 1, 2020·Molecular Nutrition & Food Research·Robert LittleGary Williamson
Dec 24, 2018·Nutrients·Phiwayinkosi V DludlaSithandiwe E Mazibuko-Mbeje
Mar 27, 2019·Nutrients·Celine HeskeyJoan Sabaté
Oct 18, 2020·Antioxidants·Mireille KoudoufioEmile Levy
Jan 15, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shifan TangYanfen Huang
Mar 7, 2021·Nutrients·Adéla KábelováOndřej Šeda
Dec 10, 2020·Food Research International·Norma Julieta Salazar-LópezG A González-Aguilar
May 22, 2020·Critical Reviews in Food Science and Nutrition·De Santis StefaniaF Corbo
Jun 24, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·N BrahmiM S Allagui