The modulation of biodistribution of stem cells by anchoring lipid-conjugated heparin on the cell surface

Journal of Controlled Release : Official Journal of the Controlled Release Society
Jong Chul Kim, Giyoong Tae

Abstract

Heparin is a bioactive glycosaminoglycan that can interact with various extracellular matrix (ECM) proteins and growth factors. Lipid-conjugated heparin was synthesized, and was used to coat adipose-derived stem cells (ADSCs) by physical insertion on the cell membrane. Coating of lipid-conjugated heparin with two lipid moieties on ADSCs was stable for 24h in vitro. Biodistribution of heparin-coated ADSCs upon intravenous injection in mice was analyzed by In-Vivo Imaging System (IVIS), and showed enhanced accumulation in the liver and spleen while reduced entrapment in the lung. Thus, the coating of ADSCs with lipid-conjugated heparin could significantly modulate the biodistribution of cells.

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 20, 2002·Angewandte Chemie·Ishan Capila, Robert J Linhardt
May 7, 2008·Biomacromolecules·Won Il ChoiYoung Ha Kim
May 9, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yasunori Mishima, Martin Lotz
Mar 7, 2009·Cell Stem Cell·Jeffrey M Karp, Grace Sock Leng Teo
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Edward N HarrisPaul H Weigel
Jun 2, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Suk ChoiYong Woo Cho
Sep 12, 2009·Drug Metabolism and Pharmacokinetics·Ger J van der Vusse
Dec 17, 2009·Biomaterials·Yuji TeramuraHiroo Iwata
Apr 15, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·In Kap KoJames E Dennis
Oct 29, 2011·Blood·Debanjan SarkarJeffrey M Karp
Oct 9, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seung Rim HwangYoungro Byun
Apr 18, 2013·Journal of the American Chemical Society·Jae Hyun JeongHyunjoon Kong
Apr 22, 2014·Journal of the American Chemical Society·Abigail PulsipherLinda C Hsieh-Wilson

❮ Previous
Next ❯

Citations

Oct 21, 2016·American Journal of Therapeutics·Sukhdeep Bhogal, Uttam Verma
Mar 20, 2021·International Journal of Pharmaceutics·Yuanqin SuJianqing Gao
May 12, 2021·ACS Applied Materials & Interfaces·Abhishek SahuGiyoong Tae
Jun 22, 2021·Journal of Investigative Medicine High Impact Case Reports·Piruthiviraj NatarajanOlufemi Aduroja
Jul 28, 2021·Expert Opinion on Drug Delivery·Yukiya TakayamaMakiya Nishikawa
Jan 18, 2018·Chemical Reviews·Jooyeon ParkHyunjoon Kong
Jun 29, 2018·ACS Applied Materials & Interfaces·Eunsol KimGiyoong Tae

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Current Stem Cell Research & Therapy
Rei Ogawa
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
Tao SHEChao-wu TANG
Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
Xiao-Hong DongJing-Bing Lang
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Yin-juan TangYing-qing Xiao
© 2021 Meta ULC. All rights reserved