PMID: 8606796Nov 1, 1995Paper

The modulation of calcium channel currents recorded from adult rat dorsal raphe neurones by 5-HT1A receptor or direct G-protein activation

Neuropharmacology
R Hamish McAllister-Williams, J S Kelly

Abstract

The effect 5-HT1A receptor activation on the temperature dependence of HVA calcium channel currents has been studied in acutely isolated DR neurones, using barium as the charge carrier. 8-OH-DPAT caused a reduction in the temperature dependence of the peak current amplitude. However the most dramatic effect of 8-OH-DPAT was a large reduction in Q10 for the current activation rate. This also occurred with direct G-protein activation using GTP gamma S. In the presence of GTP gamma S, current activation became bi-exponential, rather than mono-exponential as in the control situation. The time constants of both components were significantly slower than the controls, and the Q10 for both components was significantly lower. GDP beta S had no effect on the temperature dependence or kinetics of activation of HVA current. Depolarizing prepulses applied prior to test pulses were able to reverse the action of 8-OH-DPAT on the Q10 of the activation rate. When prepulses were applied to cells containing GTP gamma S, the activation rate Q10 was similar to control values. We postulate that the highly significant reduction in activation rate Q10, seen with both 8-OH-DPAT and GTP gamma S, is as a result of a change in the mechanism underlying act...Continue Reading

References

Jun 1, 1992·Trends in Pharmacological Sciences·W A Catterall, J Striessnig
Apr 1, 1991·The Journal of Physiology·P A Slesinger, J B Lansman
Sep 1, 1991·Brain Research. Brain Research Reviews·R Anwyl
Jan 10, 1991·Biochimica Et Biophysica Acta·A C Dolphin
Feb 1, 1986·Pflügers Archiv : European journal of physiology·C MarchettiH D Lux
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A TsunooT Narahashi
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M TakahashiW A Catterall
Aug 1, 1987·Pflügers Archiv : European journal of physiology·J R Schwarz, G Eikhof
Oct 1, 1988·Trends in Neurosciences·K P CampbellA H Sharp
Jun 1, 1989·Pflügers Archiv : European journal of physiology·H Kasai, T Aosaki
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SteaT P Snutch

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Citations

Dec 9, 2003·Trends in Molecular Medicine·Diethelm W RichterEvgeni Ponimaskin
Jul 22, 2014·Progress in Neurobiology·Stephen D MerineyCameron B Gundersen

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