The Modulation of Error Processing in the Medial Frontal Cortex by Transcranial Direct Current Stimulation

Neuroscience Journal
Lisa BellaïcheMartin J Herrmann

Abstract

Background. In order to prevent future errors, we constantly control our behavior for discrepancies between the expected (i.e., intended) and the real action outcome and continuously adjust our behavior accordingly. Neurophysiological correlates of this action-monitoring process can be studied with event-related potentials (error-related negativity (ERN) and error positivity (Pe)) originating from the medial prefrontal cortex (mPFC). Patients with neuropsychiatric diseases often show performance monitoring dysfunctions potentially caused by pathological changes of cortical excitability; therefore, a modulation of the underlying neuronal activity might be a valuable therapeutic tool. One technique which allows us to explore cortical modulation of neural networks is transcranial direct current stimulation (tDCS). Therefore, we tested the effect of medial-prefrontal tDCS on error-monitoring potentials in 48 healthy subjects randomly assigned to anodal, cathodal, or sham stimulation. Results. We found that cathodal stimulation attenuated Pe amplitudes compared to both anodal and sham stimulation, but no effect for the ERN. Conclusions. Our results indicate that cathodal tDCS over the mPFC results in an attenuated cortical excitabil...Continue Reading

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Citations

Apr 4, 2016·Journal of Neural Transmission·Katharina WietschorkeMartin J Herrmann
Apr 10, 2016·Journal of Neural Transmission·Nina VierheiligMartin J Herrmann
Dec 13, 2016·Cognitive, Affective & Behavioral Neuroscience·Aleks StolicynPeggy Seriès
Jul 12, 2018·Cognitive, Affective & Behavioral Neuroscience·Maria CotelliBarbara Borroni
Jun 20, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Miranda C LutzIngmar H A Franken
Aug 27, 2021·Journal of Motor Behavior·Elahe Nikooharf SalehiMaryam Zoghi

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Software Mentioned

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