The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model

Life Sciences
Xiaofang JiaTamie Nakajima

Abstract

Eicosapentaenoic acid (EPA) can ameliorate certain liver lesions involved in non-alcoholic steatohepatitis (NASH). A previous study has found that stroke-prone spontaneously hypertensive 5/Dmcr (SHRSP5/Dmcr) rats fed a high fat-cholesterol (HFC) diet developed fibrotic steatohepatitis with histological similarities to NASH. This study evaluated the potential effects and mechanisms of action of EPA supplementation using this rodent model. Male rats were randomly assigned to groups that were fed with either the stroke-prone (SP) diet or HFC diet with or without EPA for 2, 8 and 14 weeks, respectively. The liver histopathology, biochemical features, mRNA and protein levels, and nuclear factor-κB (NF-κB) DNA binding activity were determined. The SP diet-fed rats presented normal livers. Conversely, the HFC diet-fed rats developed microvesicular/macrovesicular steatosis, inflammation, ballooning degeneration and severe fibrosis. At 2 weeks, the administration of EPA inhibited hepatic inflammatory recruitment by blocking the phosphorylation of inhibitor of κB-α (IκBα), which antagonizes the NF-κB activation pathway. The dietary supplementation of EPA for 8 weeks ameliorated hepatic triglyceride accumulation and macrovesicular steatos...Continue Reading

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Citations

Nov 26, 2013·Purinergic Signalling·Geoffrey BurnstockSimon C Robson
Nov 6, 2014·Oxidative Medicine and Cellular Longevity·Aaron M GusdonShen Qu
Apr 27, 2013·Toxicology·Ryosuke NakashimaTamie Nakajima
Sep 29, 2015·Nihon eiseigaku zasshi. Japanese journal of hygiene·Tamie Nakajima, Hisao Naito
May 23, 2016·Environmental Health and Preventive Medicine·Hisao NaitoTamie Nakajima
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Jan 27, 2019·International Journal of Experimental Pathology·Shogo WatanabeSatoshi Hirohata
Mar 1, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Min ZhengYue-Ming Ma

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