Abstract
We have studied the in vitro effects of gold sodium thiomalate (GST) and auranofin (Auf) on the production of interleukin 1 (IL1) expressed as thymocyte co-stimulatory activity (TCSA), and interleukin 1 beta (IL1 beta) as modulated by interferon gamma (IFN gamma). Adherent cells (ADC), of which 80% were monocytes, were obtained from human peripheral blood, and stimulated with lipoprotein polysaccharide (LPS) for 24-48 h. TCSA and IL1 beta production by fresh ADC (0-24 h) was significantly higher than that of aged ADC (24-48 h). The addition of IFN gamma to ADC cultures, however, maintained the capacity of aging ADC to respond optimally to LPS. The addition of GST or Auf inhibited this modulatory effect of IFN gamma, resulting in a marked reduction of TCSA and IL1 beta production. The effects of IFN gamma on the production of IL1 may be important in the pathogenesis of rheumatoid arthritis (RA). The inhibition by GST and Auf of IFN gamma modulation may contribute to the therapeutic efficacy of these drugs in RA.
References
Mar 1, 1977·The Journal of Clinical Investigation·P E Lipsky, M Ziff
Jan 1, 1990·The Journal of Clinical Investigation·C UclaB Mach
Jul 1, 1989·The Journal of Experimental Medicine·T HoangJ C Rodriguez-Cimadevilla
Oct 1, 1985·The Journal of Experimental Medicine·J SaklatvalaY Townsend
Feb 1, 1986·The Journal of Clinical Investigation·J M DayerC A Dinarello
Dec 1, 1986·The Journal of Experimental Medicine·M A CollartP Vassalli
May 1, 1987·The Journal of Clinical Investigation·T Matsubara, M Ziff
Aug 1, 1987·Arthritis and Rheumatism·G S Firestein, N J Zvaifler
Sep 1, 1987·Arthritis and Rheumatism·K M SandersB H Littman
Apr 1, 1988·Annals of Internal Medicine·H W Murray
Oct 1, 1988·Arthritis and Rheumatism·T MatsubaraK Hirohata
Jan 1, 1988·Scandinavian Journal of Rheumatology·L RemvigN Bligaard
Aug 1, 1988·Agents and Actions·K M ConnollyT LaBrie
Feb 1, 1988·Immunological Reviews·T YokotaS Miyatake
Sep 1, 1986·The Journal of Clinical Investigation·E A RuppE K Bayne
Jun 1, 1986·The Journal of Clinical Investigation·C A DinarelloR C Reuben
Apr 1, 1985·The Journal of Clinical Investigation·M GowenR G Russell
Aug 1, 1985·Arthritis and Rheumatism·D D WoodD Hamerman
Mar 1, 1973·Annals of the Rheumatic Diseases·H M Rubinstein, A A Dietz
Dec 30, 1983·The American Journal of Medicine
Aug 1, 1983·Arthritis and Rheumatism·D D WoodP L Cohen
Citations
Jan 1, 1992·Rheumatology International
Nov 1, 1993·Agents and Actions·I A VintJ C Foreman
Jan 1, 1996·International Journal of Clinical & Laboratory Research·B DuguéR Gräsbeck
Jan 1, 1993·Molecular Aspects of Medicine·R Burrell
Dec 1, 1991·Brain, Behavior, and Immunity·J P DobbinK Cousin
Sep 1, 2001·Microbiology and Immunology·K YamaguchiW E Müller
Nov 19, 2013·Internal Medicine·Takahito NeiAkihiro Shinoyama