PMID: 15374208Sep 1, 1995Paper

The modulation of intracellular glutathione level modulates the mitochondrial response in proliferating rat splenocytes

Archives of Gerontology and Geriatrics
C PieriC Benatti

Abstract

We have investigated the effect of intracellular reduced glutathione (GSH) levels on the mitochondrial parameters of proliferating rat splenocytes. The intracellular GSH content of the cells was altered by continuous culture with buthionine-S, R-sulfoximine (BSO), a specific inhibitor of GSH synthesis. BSO decreased the GSH levels, inhibited DNA synthesis and caused depolarization of mitochondria in 52% of cells stimulated to proliferate for 72 h. These data support the proposition that GSH influences the lymphocyte proliferation at more than one site, one of which is the energy producing machinery.

References

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Citations

Aug 24, 2013·International Journal of Molecular Sciences·Serena DatoGiuseppe Passarino

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