The Modulation of Mucosal Antiviral Immunity by Immunobiotics: Could They Offer Any Benefit in the SARS-CoV-2 Pandemic?

Frontiers in Physiology
Julio Villena, Haruki Kitazawa

Abstract

Viral respiratory infections are of major importance because of their capacity to cause of a high degree of morbidity and mortality in high-risk populations, and to rapidly spread between countries. Perhaps the best example of this global threat is the infectious disease caused by the new SARS-CoV-2 virus, which has infected more than 4 million people worldwide, causing the death of 287,000 persons according to the WHO's situation report on May 13, 2020. The availability of therapeutic tools that would be used massively to prevent or mitigate the detrimental effects of emerging respiratory viruses on human health is therefore mandatory. In this regard, research from the last decade has reported the impact of the intestinal microbiota on the respiratory immunity. It was conclusively demonstrated how the variations in the intestinal microbiota affect the responses of respiratory epithelial cells and antigen presenting cells against respiratory virus attack. Moreover, the selection of specific microbial strains (immunobiotics) with the ability to modulate immunity in distal mucosal sites made possible the generation of nutritional interventions to strengthen respiratory antiviral defenses. In this article, the most important chara...Continue Reading

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Citations

Oct 6, 2020·Frontiers in Nutrition·Julio VillenaHaruki Kitazawa
Aug 12, 2020·Briefings in Bioinformatics·Zulkar NainMohammad Ali Moni
Nov 12, 2020·Microorganisms·Lakshya Sharma, Antonio Riva
Feb 9, 2021·Trends in Microbiology·Marla CunninghamGlenn R Gibson
Dec 10, 2020·Clinical and Translational Allergy·Jean BousquetUNKNOWN ARIA group
Mar 16, 2021·Frontiers in Immunology·Gislane Lelis Vilela de OliveiraCristina Ribeiro de Barros Cardoso
Apr 4, 2021·Nutrients·Oliver ChenYiFang Chu
Nov 6, 2021·Scientific Reports·Fernanda Raya-TonettiMaria Guadalupe Vizoso-Pinto

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